التفاصيل البيبلوغرافية
| العنوان: |
Collagen‐Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections |
| المؤلفون: |
Andrii Puzyrenko, Elizabeth R. Jacobs, Nathan Padilla, Adam Devine, Michael Aljadah, Benjamin N. Gantner, Amy Y. Pan, Shuping Lai, Qiang Dai, Jason C. Rubenstein, Paula E. North, Pippa M. Simpson, Rodney E. Willoughby, Caitlin C. O'Meara, Michael A. Flinn, John W. Lough, El‐Sayed H. Ibrahim, Ze Zheng, Yunguang Sun, Juan Felix, Bryan C. Hunt, Gracious Ross, Hallgeir Rui, Ivor J. Benjamin |
| المصدر: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023) |
| بيانات النشر: |
Wiley, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
cardiac fibrosis, COVID‐19, endoplasmic reticulum, heat shock proteins, human autopsy, stress, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Background Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that regulates biosynthesis and secretion of procollagen in heart tissue, with the goal of elucidating molecular mechanisms underlying cardiac fibrosis in subjects with this viral infection. Methods and Results Using human autopsy tissue, immunofluorescence, and immunohistochemistry, we quantified Hsp47+ cells and collagen α 1(l) in hearts from people with SARS‐CoV‐2 infections. Because macrophages are also linked to inflammation, we measured CD163+ cells in the same tissues. We observed irregular groups of spindle‐shaped HSP47+ and CD163+ cells as well as increased collagen α 1(I) deposition, each proximate to one another in “hot spots” of ≈40% of hearts after SARS‐CoV‐2 infection (HSP47+ P |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2047-9980 |
| Relation: |
https://doaj.org/toc/2047-9980 |
| DOI: |
10.1161/JAHA.122.027990 |
| URL الوصول: |
https://doaj.org/article/dcff5f8bd058444885b891f250ecd75e |
| رقم الانضمام: |
edsdoj.ff5f8bd058444885b891f250ecd75e |
| قاعدة البيانات: |
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