Academic Journal
أعرض في EDS

Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma

التفاصيل البيبلوغرافية
العنوان: Extracellular vesicle analysis of plasma allows differential diagnosis of atypical pancreatic serous cystadenoma
المؤلفون: Katherine S. Yang, Aileen O’Shea, Piotr Zelga, Andrew S. Liss, Carlos Fernandez Del Castillo, Ralph Weissleder
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Increased use of cross-sectional imaging has resulted in frequent detection of incidental cystic pancreatic lesions. Serous cystadenomas (SCAs) are benign cysts that do not require surgical intervention unless symptomatic. Unfortunately, up to half of SCAs do not have typical imaging findings (“atypical SCAs”), overlap with potentially malignant precursor lesions, and thus pose a diagnostic challenge. We tested whether the analysis of circulating extracellular vesicle (EV) biomarkers using a digital EV screening technology (DEST) could enhance the discrimination of cystic pancreatic lesions and avoid unnecessary surgical intervention in these atypical SCAs. Analysis of 25 different protein biomarkers in plasma EV from 68 patients identified a putative biomarker signature of Das-1, Vimentin, Chromogranin A, and CAIX with high discriminatory power (AUC of 0.99). Analysis of plasma EV for multiplexed markers may thus be helpful in clinical decision-making.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-37966-5
URL الوصول: https://doaj.org/article/fe4406069db644c5bb5fdeae08b32dc2
رقم الانضمام: edsdoj.fe4406069db644c5bb5fdeae08b32dc2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-023-37966-5