Academic Journal
Barbatic Acid Offers a New Possibility for Control of Biomphalaria Glabrata and Schistosomiasis
| العنوان: | Barbatic Acid Offers a New Possibility for Control of Biomphalaria Glabrata and Schistosomiasis |
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| المؤلفون: | Mônica Cristina Barroso Martins, Monique Costa Silva, Hianna Arely Milca Fagundes Silva, Luanna Ribeiro Santos Silva, Mônica Camelo Pessoa de Azevedo Albuquerque, André Lima Aires, Emerson Peter da Silva Falcão, Eugênia C. Pereira, Ana Maria Mendonça Albuquerque de Melo, Nicácio Henrique da Silva |
| المصدر: | Molecules, Vol 22, Iss 4, p 568 (2017) |
| بيانات النشر: | MDPI AG, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Organic chemistry |
| مصطلحات موضوعية: | Cladia aggregata, embryotoxicity, molluscicidal activity, environmental toxicity, lichen substances, mollusks, Organic chemistry, QD241-441 |
| الوصف: | This study evaluated the biological activity of an ether extract and barbatic acid (BAR) from Cladia aggregata on embryos and adult mollusks of Biomphalaria glabrata, cercariae of Schistosoma mansoni and the microcrustacean Artemia salina. The ether extract and BAR were obtained by successive extractions with diethyl ether. The obtained extracts were analyzed using thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), proton nuclear magnetic resonance (1H-NMR) and infrared (IR) spectroscopy. The results demonstrated that the ether extract exerted embryotoxic effects at 50 and 100 µg/mL and molluscicidal effects at 20 and 25 µg/mL. BAR exhibited no embryotoxicity, and its molluscicidal concentration was equal to that of the ether extract. However, after 60 min of exposure, 1 µg/mL BAR presented cercaricidal activity against the parasite S. mansoni at the second larval stage. Neither substance induced toxicity against A. salina. These results indicate the potential molluscicidal activities of the ether extract and BAR against B. glabrata and S. mansoni cercariae. In addition to these effects, there was a lack of toxicity against the aquatic environment and no damage to the biota, indicating the potential of these products for large-scale control and/or eradication of schistosomiasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-3049 42559499 |
| Relation: | http://www.mdpi.com/1420-3049/22/4/568; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules22040568 |
| URL الوصول: | https://doaj.org/article/fe3e14b425594998a9756cc18ac7550b |
| رقم الانضمام: | edsdoj.fe3e14b425594998a9756cc18ac7550b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14203049 42559499 |
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| DOI: | 10.3390/molecules22040568 |