التفاصيل البيبلوغرافية
| العنوان: |
Effects of the Ordering of Natural Selection and Population Regulation Mechanisms on Wright-Fisher Models |
| المؤلفون: |
Zhangyi He, Mark Beaumont, Feng Yu |
| المصدر: |
G3: Genes, Genomes, Genetics, Vol 7, Iss 7, Pp 2095-2106 (2017) |
| بيانات النشر: |
Oxford University Press, 2017. |
| سنة النشر: |
2017 |
| المجموعة: |
LCC:Genetics |
| مصطلحات موضوعية: |
Wright-Fisher model, viability selection, fecundity selection, linkage disequilibrium, Genetics, QH426-470 |
| الوصف: |
We explore the effect of different mechanisms of natural selection on the evolution of populations for one- and two-locus systems. We compare the effect of viability and fecundity selection in the context of the Wright-Fisher model with selection under the assumption of multiplicative fitness. We show that these two modes of natural selection correspond to different orderings of the processes of population regulation and natural selection in the Wright-Fisher model. We find that under the Wright-Fisher model these two different orderings can affect the distribution of trajectories of haplotype frequencies evolving with genetic recombination. However, the difference in the distribution of trajectories is only appreciable when the population is in significant linkage disequilibrium. We find that as linkage disequilibrium decays the trajectories for the two different models rapidly become indistinguishable. We discuss the significance of these findings in terms of biological examples of viability and fecundity selection, and speculate that the effect may be significant when factors such as gene migration maintain a degree of linkage disequilibrium. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2160-1836 |
| Relation: |
https://doaj.org/toc/2160-1836 |
| DOI: |
10.1534/g3.117.041038 |
| URL الوصول: |
https://doaj.org/article/efe1207f8ae443d5af4c48546ff27179 |
| رقم الانضمام: |
edsdoj.fe1207f8ae443d5af4c48546ff27179 |
| قاعدة البيانات: |
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