Academic Journal
The dynamics of immunological parameters in early stages after bilateral lung transplantation in patients with various pulmonary pathology
| العنوان: | The dynamics of immunological parameters in early stages after bilateral lung transplantation in patients with various pulmonary pathology |
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| المؤلفون: | M. Sh. Khubutiya, E. A. Tarabrin, E. I. Pervakova, V. P. Nikulina, M. A. Godkov |
| المصدر: | Трансплантология (Москва), Vol 10, Iss 4, Pp 274-283 (2018) |
| بيانات النشر: | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | lung transplantation, graft dysfunction, immune response, lymphocytes, immunoglobulins, Medicine |
| الوصف: | Background. The diseases leading to the need for lung transplantation include chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, alpha-1-antitrypsin deficiency, idiopathic pulmonary hypertension, histiocytosis X, and sarcoidosis. Primary lung transplant dysfunction is a frequent complication after transplantation and represents a multifactorial injury of the transplanted lung, its pathogenesis being associated with a severe hypoxemia of the lung transplant and diffused damage to the alveoli. The clinical presentation is in many ways similar to an acute respiratory distress syndrome, which pathogenesis is primarily effected by the activation of immune system cells. The cytokine production by immunocompetent cells, the synthesis of reactive oxygen and nitrous oxide, being the mediators of inflammation, trigger inflammatory processes in the lungs; the immunoglobulin synthesis derangements also lead to the development of inflammatory abnormalities in the lungs and a poor transplantation outcome.The objective was to study the immunological response in the lung transplant recipients suffering from the underlying disease of various etiology and to determine the immunological predictors of adverse outcome in the early period after bilateral lung transplantation.Material and methods. Twenty nine patients were examined within 2 weeks after lung transplantation: Group 1 comprised 10 patients with cystic fibrosis (6 women, 4 men) aged 27.8 ± 2.7 years; Group 2 included 19 patients (7 women, 12 men) at the age of 38.5 ± 10.4 years having other lung diseases. Mortality was 10% (1 patient) in Group 1, and 52.5% (10 patients) in Group 2. The patients were followed-up according to the standard protocol of postoperative treatment and immunosuppression therapy shemes. Immunological monitoring included the lymphocyte phenotyping, and the assessment of phagocytic activity of neutrophils, the HCT-test, the blood levels of immunoglobulins (Ig) A, M, G, circulating immune complexes, and C-reactive protein. Statistical significance was assessed at p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Russian |
| تدمد: | 2074-0506 2542-0909 |
| Relation: | https://www.jtransplantologiya.ru/jour/article/view/403; https://doaj.org/toc/2074-0506; https://doaj.org/toc/2542-0909 |
| DOI: | 10.23873/2074-0506-2018-10-4-274-283 |
| URL الوصول: | https://doaj.org/article/fdd62e56ddc743a899cfd830f7403489 |
| رقم الانضمام: | edsdoj.fdd62e56ddc743a899cfd830f7403489 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 20740506 25420909 |
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| DOI: | 10.23873/2074-0506-2018-10-4-274-283 |