التفاصيل البيبلوغرافية
| العنوان: |
Residual radiological opacities correlate with disease outcomes in ICU-treated COVID-19 |
| المؤلفون: |
Mikael Björnson, Ann Mari Svensson, Cecilia He, Magnus Sköld, Sven Nyrén, Malin Nygren-Bonnier, Judith Bruchfeld, Michael Runold, Francesca Campoccia Jalde, Anna Kistner |
| المصدر: |
Frontiers in Medicine, Vol 11 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
COVID-19, computed tomography, spirometry, exercise test, pulmonary diffusing capacity, residual radiological opacities, Medicine (General), R5-920 |
| الوصف: |
BackgroundFew studies consider both radiological and functional outcomes in COVID-19 survivors treated in the intensive care unit (ICU). We investigated clinical findings and pulmonary abnormalities on chest computed tomography (CT) and compared outcomes of severe versus mild-moderate acute respiratory distress syndrome (ARDS) on long-term follow-up.MethodsThis longitudinal cohort study included 118 COVID-19 patients (median age, 58 years; 79% men). Thoracic CT scans were performed 4, 10, and 22 months after hospital discharge. Two independent blinded radiologists analyzed the 10 months scans and scored the radiology findings semi-quantitatively, as no/minor versus widespread opacities [low-radiology opacity grade (ROG) versus high-ROG]. ARDS severity was based on the PaO2/FiO2 ratio. The 6 min walk test (6MWT) was performed after 3 and 9 months, and lung diffusion capacity for carbon monoxide (DLCO) and lung volume measurement after 9 and 15 months. Dynamic spirometry was done at all time points. Residual symptoms and health-related quality-of-life (HRQL) were evaluated using validated questionnaires.ResultsAt 10 months, most patients (81/118; 69%) were classified as high-ROG, of which 70% had severe ARDS during hospitalisation; 69% of those with mild-moderate ARDS also had high-ROG. Patients with high-ROG had longer ICU stay and lower PaO2/FiO2 during hospitalisation (p 25%) in most patients at follow-up at 10 months (AUC 0.74).ConclusionResidual radiological abnormalities in ICU-treated COVID-19 patients, evaluated for up to 2 years, relate to persisting symptoms and impaired lung function, demanding careful follow-up regardless of ARDS severity at hospitalisation. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-858X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmed.2024.1263511/full; https://doaj.org/toc/2296-858X |
| DOI: |
10.3389/fmed.2024.1263511 |
| URL الوصول: |
https://doaj.org/article/cfdd37f83eaa44cf96b0fd8d6f18c739 |
| رقم الانضمام: |
edsdoj.fdd37f83eaa44cf96b0fd8d6f18c739 |
| قاعدة البيانات: |
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