Academic Journal
Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia
| العنوان: | Protective Effect of Panicum dichotomiflorum in a Rodent Model of Testosterone-Induced Benign Prostatic Hyperplasia |
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| المؤلفون: | Eun Bok Baek, Eun-Ju Hong, Jung-Hee Kim, Min Kim, Jongmin Ahn, Hyo-Jung Kwun |
| المصدر: | Scientia Pharmaceutica, Vol 92, Iss 1, p 13 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | apoptosis, benign prostatic hyperplasia, growth factor, inflammation, Panicum dichotomiflorum, proliferation, Pharmacy and materia medica, RS1-441 |
| الوصف: | Benign prostatic hyperplasia (BPH) is a common disease in aging men. Panicum dichotomiflorum (PD) is an annual grass species of Poaceae that is distributed worldwide. The present study examined whether PD has a protective effect against BPH. BPH was generated in rats by daily subcutaneous administration of testosterone for four weeks. During this period, the rats were also given daily oral gavages of an extract of PD (150 mg/kg). After the final treatment, all animals were euthanized and their prostates were collected and weighed. In BPH model rats, the prostate weight and levels of dihydrotestosterone (DHT) and 5α-reductase expression were inhibited following treatment with PD extract. Testosterone-induced increases in prostate gland epithelial thickness and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA) were markedly suppressed in PD-treated rats, whereas cleaved caspase-3 levels were increased. PD administration also decreased the expression of transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF), the phosphorylation of Akt, and inflammatory cytokines levels. Taken together, these results show that PD extract protects against testosterone-induced BPH progression by alleviating prostate cell growth and reducing levels of growth factors and inflammatory cytokines, indicating that PD extract may have potential in protecting against BPH. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2218-0532 0036-8709 |
| Relation: | https://www.mdpi.com/2218-0532/92/1/13; https://doaj.org/toc/0036-8709; https://doaj.org/toc/2218-0532 |
| DOI: | 10.3390/scipharm92010013 |
| URL الوصول: | https://doaj.org/article/dedfc21959c84252af55fea2be7e8f86 |
| رقم الانضمام: | edsdoj.fc21959c84252af55fea2be7e8f86 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22180532 00368709 |
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| DOI: | 10.3390/scipharm92010013 |