التفاصيل البيبلوغرافية
| العنوان: |
Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity |
| المؤلفون: |
Yan Zhu, Junjiu Xu, Zhao Li, Shuwu Xie, Jieyun Zhou, Xiangjie Guo, Xianying Zhou, Guoting Li, Ruihua Zhong, Aying Ma |
| المصدر: |
Journal of Functional Foods, Vol 18, Iss , Pp 73-82 (2015) |
| بيانات النشر: |
Elsevier, 2015. |
| سنة النشر: |
2015 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
Ginsenoside Rh2, ERα, c-Src, p38 MAPK, Uterine leiomyoma, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
Panax ginseng is widely used as a functional food in Asia because of its bioactivities. Here, we report that ginsenoside Rh2, an extract of red Panax ginseng, suppressed growth of uterine leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent manner. Rh2 also inhibited the growth of cultured human UL cells in vitro. After Rh2 treatment, cells showed morphological changes that were consistent with apoptosis. Using ELISA, real-time RT-PCR, and Western blot methods, we found that Rh2 significantly reduced the activity of oestrogen receptor alpha (ERα) and c-Src, increased p38 MAPK activity, and reversed ERα activity mediated by PP2 and SB203580, specific inhibitors of c-Src and p38 MAPK, respectively, in UL cells. These findings provide a novel mechanism for the anti-proliferative efficacy of Rh2 that likely involves regulating ERα/Src/p38 MAPK activity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1756-4646 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1756464615003515; https://doaj.org/toc/1756-4646 |
| DOI: |
10.1016/j.jff.2015.06.057 |
| URL الوصول: |
https://doaj.org/article/fbc70c36749a4c78811181ec1655ab07 |
| رقم الانضمام: |
edsdoj.fbc70c36749a4c78811181ec1655ab07 |
| قاعدة البيانات: |
Directory of Open Access Journals |