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Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice

التفاصيل البيبلوغرافية
العنوان: Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice
المؤلفون: Xiaolin Zhang, Yunqing Wang, Xiaohan Tong, Boqing Li, Sisi Liu, Yingzi Cui, Wenke Wang, Zhiqin Li, Chunlei Ma, Ying Zhang
المصدر: Ecotoxicology and Environmental Safety, Vol 290, Iss , Pp 117757- (2025)
بيانات النشر: Elsevier, 2025.
سنة النشر: 2025
المجموعة: LCC:Environmental pollution
LCC:Environmental sciences
مصطلحات موضوعية: Helicobacter pylori, Nanoplastics, Co-exposure, Oxidative stress, Inflammatory response, Energy metabolism dysregulation, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350
الوصف: Nanoplastics, in combination with pathogenic microorganisms or toxic substances, have been shown to induce oxidative stress and disrupt energy and lipid metabolism, posing significant health risks. This study evaluated the toxic effects of co-exposure to nanoplastics and Helicobacter pylori on the digestive system of mice. Transmission electron microscopy confirmed the accumulation of AuPS-NPs (Au-core polystyrene nanoplastics) in the stomach, colon, and liver, while hematoxylin and eosin staining revealed dose-dependent pathological damage in these tissues. Enzyme-linked immunosorbent assays quantified interleukin-6 (IL-6), malondialdehyde (MDA), triglyceride (TG), and lactate dehydrogenase (LDH) levels, which significantly increased in co-exposure groups compared to single-exposure groups (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 0147-6513
Relation: http://www.sciencedirect.com/science/article/pii/S0147651325000934; https://doaj.org/toc/0147-6513
DOI: 10.1016/j.ecoenv.2025.117757
URL الوصول: https://doaj.org/article/afb775399e974499bad2988f43c00907
رقم الانضمام: edsdoj.fb775399e974499bad2988f43c00907
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:01476513
DOI:10.1016/j.ecoenv.2025.117757