Academic Journal
Assessment of growth retardation among transfusion-dependent Thalassemia patients in Peshawar, Pakistan
| العنوان: | Assessment of growth retardation among transfusion-dependent Thalassemia patients in Peshawar, Pakistan |
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| المؤلفون: | Adil Zareef, Farrukh Ansar, Aamir Ali Khan, Muhammad Tariq Masood Khan, Farooq Shah |
| المصدر: | Khyber Medical University Journal, Vol 16, Iss 3, Pp 207-12 (2024) |
| بيانات النشر: | Khyber Medical University, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | transfusion, thalassemia major, beta-thalassemia, ferritins, hyperferritinemia, iron overload, growth retardation, fetal growth restriction, growth retardation, intrauterine, body mass index, transfusion-dependent thalassemia, Medicine |
| الوصف: | OBJECTIVE: To investigate the relationship between repeated blood transfusions and growth retardation in children with transfusion-dependent Thalassemia in Peshawar, Pakistan. METHODS: This cross-sectional study was conducted on transfusion-dependent thalassemia patients receiving treatment at the Fatimid Foundation, Peshawar Pakistan, between February and August 2022. Participants were categorized by age (2 years) to assess and measure growth patterns over six months. RESULTS: Out of 93 children with thalassemia major, 55 (59.1%) males and 38 (40.9%) females. Mean age of the participants was 10.86 ± 5.72 years, and mean age at their first transfusion was 8.13 ± 5.78 months. Mean body mass index was 16.38 ± 1.82 kg/m². Short stature was observed in 49 patients (52.7%), of whom 57.1% (n=28) were male and 42.9% (n=21) were female. Serum ferritin levels were significantly elevated in patients with short stature, with 57.1% (n=28/49) having ferritin levels >4001 μg/L compared to 40.9% (n=18/44) with normal stature. Only 3.2% of patients had normal ferritin levels. The ROC analysis identified a ferritin cut-off of 1636 μg/L for predicting short stature (sensitivity 86%, specificity 68%). Growth assessment showed that 71% of the children were |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2305-2643 2305-2651 |
| Relation: | https://www.kmuj.kmu.edu.pk/article/view/23505; https://doaj.org/toc/2305-2643; https://doaj.org/toc/2305-2651 |
| DOI: | 10.35845/kmuj.2024.23505 |
| URL الوصول: | https://doaj.org/article/fb524762a4674af5867ca47bbfd25be8 |
| رقم الانضمام: | edsdoj.fb524762a4674af5867ca47bbfd25be8 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23052643 23052651 |
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| DOI: | 10.35845/kmuj.2024.23505 |