Academic Journal

Association between perioperative statin treatment and short-term clinical outcomes following transcatheter aortic valve implantation: a retrospective cohort study

التفاصيل البيبلوغرافية
العنوان: Association between perioperative statin treatment and short-term clinical outcomes following transcatheter aortic valve implantation: a retrospective cohort study
المؤلفون: Michiel Voskuil, Anthonius de Boer, Marcel Bouvy, Wilma Knol, Huiberdina L Koek, Adriaan O Kraaijeveld, Lauren Dautzenberg, Marielle Emmelot-Vonk, Geert Lefeber, Carla Huijbers
المصدر: Open Heart, Vol 10, Iss 2 (2023)
بيانات النشر: BMJ Publishing Group, 2023.
سنة النشر: 2023
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Background Studies have found statin treatment to be associated with improved 1-year survival after transcatheter aortic valve implantation (TAVI), suggesting pleiotropic effects of statins on preventing perioperative complications. Statin treatment is not associated with postoperative cardiovascular complications or mortality; however, other postoperative complications have not been investigated.Aim To explore whether preoperative statin treatment is associated with a lower short-term risk of mortality, readmission and major postoperative complications in older patients undergoing TAVI.Methods A retrospective cohort study including patients aged 65 years and older who had undergone a comprehensive geriatric assessment prior to TAVI between January 2014 and January 2021. The primary outcomes were 90-day mortality, 90-day readmissions and major postoperative complications according to the Clavien-Dindo classification. Multivariable logistic regression was performed with adjustment for potential confounders, namely age, gender, comorbidity, body mass index, smoking, diminished renal function, alcohol use and falls .Results This study included 584 patients, of whom 324 (55.5%) were treated with a statin. In the statin treated group, 15 (4.6%) patients died within 90 days of TAVI compared with 10 (3.8%) patients in the non statin group (adjusted OR 1.17; 95% CI 0.51 to 2.70). The number of 90-day readmissions was 39 (12.0%) and 34 (13.1%) (adjusted OR 0.91; 95% CI 0.54 to 1.52), respectively. In the statin treated group, 115 (35.5%) patients experienced a major complication compared with 98 (37.7%) in the non-statin group (adjusted OR 0.95; 95% CI 0.67 to 1.37).Conclusion Preoperative statin treatment is not associated with improved short-term outcomes after TAVI. A randomised controlled trial with different statin doses may be warranted to investigate whether initiating statin treatment before TAVI improves both postoperative outcomes and long-term survival.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2053-3624
Relation: https://openheart.bmj.com/content/10/2/e002348.full; https://doaj.org/toc/2053-3624
DOI: 10.1136/openhrt-2023-002348
URL الوصول: https://doaj.org/article/fb51e6d8fc0a4e2aa579255c8d7d1ac6
رقم الانضمام: edsdoj.fb51e6d8fc0a4e2aa579255c8d7d1ac6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20533624
DOI:10.1136/openhrt-2023-002348