Academic Journal

De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens

التفاصيل البيبلوغرافية
العنوان: De Novo Design of Antimicrobial Peptides With a Special Charge Pattern and Their Application in Combating Plant Pathogens
المؤلفون: Eric H. -L. Chen, Cheng-Wei Weng, Yi-Min Li, Ming-Chin Wu, Chien-Chih Yang, Kung-Ta Lee, Rita P. -Y. Chen, Chiu-Ping Cheng
المصدر: Frontiers in Plant Science, Vol 12 (2021)
بيانات النشر: Frontiers Media S.A., 2021.
سنة النشر: 2021
المجموعة: LCC:Plant culture
مصطلحات موضوعية: antimicrobial peptides, bacteria, fungi, membrane permeability, plant diseases, plant protection, Plant culture, SB1-1110
الوصف: Plant diseases are important issues in agriculture, and the development of effective and environment-friendly means of disease control is crucial and highly desired. Antimicrobial peptides (AMPs) are known as potential alternatives to chemical pesticides because of their potent broad-spectrum antimicrobial activity and because they have no risk, or have only a low risk, of developing chemical-resistant pathogens. In this study, we designed a series of amphipathic helical peptides with different spatial distributions of positive charges and found that the peptides that had a special sequence pattern “BBHBBHHBBH” (“B” for basic residue and “H” for hydrophobic residue) displayed excellent bactericidal and fungicidal activities in a wide range of economically important plant pathogens. The peptides with higher helical propensity had lower antimicrobial activity. When we modified the peptides with a long acyl chain at their N-terminus, their plant protection effect improved. Our application of the fatty acyl-modified peptides on the leaves of tomato and Arabidopsis plants lessened the infection caused by Pectobacterium carotovorum subsp. carotovorum and Botrytis cinerea. Our study provides important insights on the development of more potent novel AMPs for plant protection.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1664-462X
Relation: https://www.frontiersin.org/articles/10.3389/fpls.2021.753217/full; https://doaj.org/toc/1664-462X
DOI: 10.3389/fpls.2021.753217
URL الوصول: https://doaj.org/article/fb03dd1c0b194261a6475be71507fea6
رقم الانضمام: edsdoj.fb03dd1c0b194261a6475be71507fea6
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1664462X
DOI:10.3389/fpls.2021.753217