Academic Journal
A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation
| العنوان: | A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation |
|---|---|
| المؤلفون: | Peifeng Tang, Jianlin Xu, Christopher L. Oliveira, Zheng Jian Li, Shijie Liu |
| المصدر: | Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 564-571 (2017) |
| بيانات النشر: | Taylor & Francis Group, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Cancer diagnosis, inhibitor evaluation, kinetic model, lactate dehydrogenase, oligomeric enzyme, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | As a key enzyme for glycolysis, lactate dehydrogenase (LDH) remains as a topic of great interest in cancer study. Though a number of kinetic models have been applied to describe the dynamic behavior of LDH, few can reflect its actual mechanism, making it difficult to explain the observed substrate and competitor inhibitions at wide concentration ranges. A novel mechanistic kinetic model is developed based on the enzymatic processes and the interactive properties of LDH. Better kinetic simulation as well as new enzyme interactivity information and kinetic properties extracted from published articles via the novel model was presented. Case studies were presented to a comprehensive understanding of the effect of temperature, substrate, and inhibitor on LDH kinetic activities for promising application in cancer diagnosis, inhibitor evaluation, and adequate drug dosage prediction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-6366 1475-6374 14756366 |
| Relation: | https://doaj.org/toc/1475-6366; https://doaj.org/toc/1475-6374 |
| DOI: | 10.1080/14756366.2016.1275606 |
| URL الوصول: | https://doaj.org/article/fb0365afc94b45b781721c720ec883b6 |
| رقم الانضمام: | edsdoj.fb0365afc94b45b781721c720ec883b6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14756366 14756374 |
|---|---|
| DOI: | 10.1080/14756366.2016.1275606 |