Academic Journal
Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae
| العنوان: | Transport of soluble proteins through the Golgi occurs by diffusion via continuities across cisternae |
|---|---|
| المؤلفون: | Galina V Beznoussenko, Seetharaman Parashuraman, Riccardo Rizzo, Roman Polishchuk, Oliviano Martella, Daniele Di Giandomenico, Aurora Fusella, Alexander Spaar, Michele Sallese, Maria Grazia Capestrano, Margit Pavelka, Matthijn R Vos, Yuri GM Rikers, Volkhard Helms, Alexandre A Mironov, Alberto Luini |
| المصدر: | eLife, Vol 3 (2014) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | intracellular trafficking, soluble cargo protein, albumin, golgi complex, membrane tubule, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | The mechanism of transport through the Golgi complex is not completely understood, insofar as no single transport mechanism appears to account for all of the observations. Here, we compare the transport of soluble secretory proteins (albumin and α1-antitrypsin) with that of supramolecular cargoes (e.g., procollagen) that are proposed to traverse the Golgi by compartment progression–maturation. We show that these soluble proteins traverse the Golgi much faster than procollagen while moving through the same stack. Moreover, we present kinetic and morphological observations that indicate that albumin transport occurs by diffusion via intercisternal continuities. These data provide evidence for a transport mechanism that applies to a major class of secretory proteins and indicate the co-existence of multiple intra-Golgi trafficking modes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/02009; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.02009 |
| URL الوصول: | https://doaj.org/article/edfa84eb765c487596b6ad0eb4a5fa18 |
| رقم الانضمام: | edsdoj.fa84eb765c487596b6ad0eb4a5fa18 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
|---|---|
| DOI: | 10.7554/eLife.02009 |