Academic Journal
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS
| العنوان: | Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS |
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| المؤلفون: | María C. García-Hidalgo, Jessica González, Iván D. Benítez, Paola Carmona, Sally Santisteve, Manel Pérez-Pons, Anna Moncusí-Moix, Clara Gort-Paniello, Fátima Rodríguez-Jara, Marta Molinero, Thalia Belmonte, Gerard Torres, Gonzalo Labarca, Estefania Nova-Lamperti, Jesús Caballero, Jesús F. Bermejo-Martin, Adrián Ceccato, Laia Fernández-Barat, Ricard Ferrer, Dario Garcia-Gasulla, Rosario Menéndez, Ana Motos, Oscar Peñuelas, Jordi Riera, Antoni Torres, Ferran Barbé, David de Gonzalo-Calvo |
| المصدر: | Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1537-1549 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| مصطلحات موضوعية: | Acute respiratory distress syndrome, COVID-19, lung function, microRNA, sequelae, total severity score, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| الوصف: | There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n = 167) and a group of infected patients who did not develop ARDS (n = 33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (DLCO) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. DLCO |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 22221751 2222-1751 |
| Relation: | https://doaj.org/toc/2222-1751 |
| DOI: | 10.1080/22221751.2022.2081615 |
| URL الوصول: | https://doaj.org/article/cfa5e39c67384de6ada9459646d423c5 |
| رقم الانضمام: | edsdoj.fa5e39c67384de6ada9459646d423c5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22221751 |
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| DOI: | 10.1080/22221751.2022.2081615 |