Academic Journal
Prophylactic cranial irradiation in patients with resected small‐cell lung cancer: A systematic review and meta‐analysis
| العنوان: | Prophylactic cranial irradiation in patients with resected small‐cell lung cancer: A systematic review and meta‐analysis |
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| المؤلفون: | Haoning Peng, Jianqi Hao, Bo Dong, Minqi Chen, Zongyuan Li, Cong Chen, Lunxu Liu |
| المصدر: | Thoracic Cancer, Vol 15, Iss 32, Pp 2309-2318 (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | cranial irradiation, small‐cell lung carcinoma, thoracic surgery, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Prophylactic cranial irradiation (PCI) was recommended for limited‐stage small‐cell lung cancer (SCLC) patients with complete or partial response to primary chemoradiotherapy. But it is still controversial regarding its role in SCLC patients who have had radical resection. This meta‐analysis aims to evaluate the efficacy of PCI in resected SCLC patients. We searched PubMed, EMBASE, Web of Science, CENTRAl, and ClinicalTrials for controlled trials and cohort studies regarding PCI in postoperative SCLC patients. The correlation between PCI and post‐operative outcomes in SCLC patients, including survival and brain metastasis rate (BMR), was examined using hazard ratios (HRs) and risk ratios with corresponding 95% confidence intervals. Quality of studies was assessed by the Newcastle–Ottawa Scale (NOS), and publication bias was assessed by Begg's test. Meta‐analysis of eight studies with 2688 patients in total showed PCI was associated with improved overall survival (OS) for resected SCLC (HR: 0.65, 95% CI: 0.57–0.75, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.15463 |
| URL الوصول: | https://doaj.org/article/efa130c76bd74b1eb09633e027194fea |
| رقم الانضمام: | edsdoj.fa130c76bd74b1eb09633e027194fea |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.15463 |