التفاصيل البيبلوغرافية
| العنوان: |
The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K |
| المؤلفون: |
Grzegorz B. Wasilewski, Marc G. Vervloet, Leon J. Schurgers |
| المصدر: |
Frontiers in Cardiovascular Medicine, Vol 6 (2019) |
| بيانات النشر: |
Frontiers Media S.A., 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
calcium paradox, vitamin K, vascular calcification, calcium supplements, bone loss, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Calcium supplements are broadly prescribed to treat osteoporosis either as monotherapy or together with vitamin D to enhance calcium absorption. It is still unclear whether calcium supplementation significantly contributes to the reduction of bone fragility and fracture risk. Data suggest that supplementing post-menopausal women with high doses of calcium has a detrimental impact on cardiovascular morbidity and mortality. Chronic kidney disease (CKD) patients are prone to vascular calcification in part due to impaired phosphate excretion. Calcium-based phosphate binders further increase risk of vascular calcification progression. In both bone and vascular tissue, vitamin K-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin K supplementation might protect from the potentially untoward effects of calcium supplementation. This review provides an update on current literature on calcium supplementation among post-menopausal women and CKD patients and discusses underlying molecular mechanisms of vascular calcification. We propose therapeutic strategies with vitamin K2 treatment to prevent or hold progression of vascular calcification as a consequence of excessive calcium intake. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2297-055X |
| Relation: |
https://www.frontiersin.org/article/10.3389/fcvm.2019.00006/full; https://doaj.org/toc/2297-055X |
| DOI: |
10.3389/fcvm.2019.00006 |
| URL الوصول: |
https://doaj.org/article/f8bc1ea789e744b6a2ccfdd385d6a685 |
| رقم الانضمام: |
edsdoj.f8bc1ea789e744b6a2ccfdd385d6a685 |
| قاعدة البيانات: |
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