Academic Journal
Usefulness of serum S100A4 and positron‐emission tomography on lung cancer accompanied by interstitial pneumonia
| العنوان: | Usefulness of serum S100A4 and positron‐emission tomography on lung cancer accompanied by interstitial pneumonia |
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| المؤلفون: | Atsushi Kagimoto, Yasuhiro Tsutani, Kei Kushitani, Takahiro Kambara, Takahiro Mimae, Yoshihiro Miyata, Yukio Takeshima, Morihito Okada |
| المصدر: | Thoracic Cancer, Vol 14, Iss 4, Pp 381-388 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | FDG‐PET/CT, interstitial pneumonia, lung cancer, S100A4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background The S100 calcium‐binding protein A4 (S100A4) and the accumulation of [18F]‐fluoro‐2‐deoxy‐D‐glucose (FDG) in noncancerous interstitial pneumonia (IP) area are predictors of postoperative acute exacerbation (AE) of IP after pulmonary resection for lung cancer with IP. However, the significance of combining these markers for predicting short‐term outcome and long‐term prognosis is not known. Methods Patients diagnosed with IP on preoperative high‐resolution computed tomography and who had undergone pulmonary resection for primary lung cancer between April 2010 and March 2019 at Hiroshima University were included in this study. Predictive factors for the cumulative incidence of death from other than lung cancer (CIDOL) were investigated using the Fine and Gray model. CIDOL, perioperative outcome, and cumulative incidence of all death (CIAD) were retrospectively compared based on serum S100A4 and FDG accumulation. Results A total of 121 patients were included in this study. High S100A4 (hazard ratio [HR], 2.541; p = 0.006) and FDG accumulation (HR, 3.199; p = 0.038) were significant predictors of CIDOL. AE of IP occurred only in patients with high S100A4/FDG (+). CIDOL of patients with high S100A4/FDG (+) was higher than those with high S100A4/FDG (−) or low S100A4/FDG (+) (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.14757 |
| URL الوصول: | https://doaj.org/article/f7bccb167c6c43f68e4fe08ef387262a |
| رقم الانضمام: | edsdoj.f7bccb167c6c43f68e4fe08ef387262a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.14757 |