Academic Journal
Serum Nesfatin-1 in patients with type 2 diabetes mellitus: A cross sectional study
| العنوان: | Serum Nesfatin-1 in patients with type 2 diabetes mellitus: A cross sectional study |
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| المؤلفون: | Niyan Jassim Mohammad, Dler Qader Gallaly |
| المصدر: | Zanco Journal of Medical Sciences, Vol 24, Iss 1, Pp 1-7 (2020) |
| بيانات النشر: | Hawler Medical University, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | type 2 diabetes mellitus, nesfatin-1, homeostasis model assessment of insulin resistance, glycated hemoglobin, Medicine |
| الوصف: | Background and objective: Nesfatin-1 is a newly described peptide, derived from nucleobindin2. Nesfatin-1 suppresses food intake and it is involved in regulating insulin secretion. The aim of this study was to compare serum levels of Nesfatin-1 in patients having type 2 diabetes and non-diabetic subjects. Methods: This cross-sectional study included 90 participants; 64 patients with type 2 diabetes mellitus (32 males and 32 females) and 26 control subjects (13 males and 13 female). Body mass index, fasting serum level of glucose, fasting serum level of insulin, and glycated hemoglobin were estimated. Homeostasis model assessment of insulin resistance was calculated. Nesfatin-1 level was measured using enzyme-linked immune-sorbent assay kit. The data was analyzed using Graphpad prism 7.04 for windows. Results: Type 2 diabetes patients aged from 33-78 years and the control group aged from 32-75 years. Nesfatin-1 level in the diabetic group was significantly lower than controls. The median interquartile range (IQR) of Nesfatin-1 was 0.765 (0.4-1.173) in diabetes and 1.02 (0.775-1.458) in controls. The diabetes group has significantly higher homeostasis model assessment of insulin resistance compared with non-diabetics. Serum Nesfatin-1 was correlated negatively with body mass index, fasting serum glucose, fasting serum insulin, glycatedhemoglobin, and homeostasis assessment of insulin resistance. Conclusion: Serum Nesfatin-1 level is negatively correlated with fasting serum glucose, fasting serum insulin, and glycated hemoglobin. This association supports the role of Nesfatin-1 in increased insulin resistance in patients with type 2 diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1995-5588 1995-5596 |
| Relation: | https://zjms.hmu.edu.krd/index.php/zjms/article/view/716/615; https://doaj.org/toc/1995-5588; https://doaj.org/toc/1995-5596 |
| DOI: | 10.15218/zjms.2020.001 |
| URL الوصول: | https://doaj.org/article/f753f9bec088485497ebbbf81f125724 |
| رقم الانضمام: | edsdoj.f753f9bec088485497ebbbf81f125724 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 19955588 19955596 |
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| DOI: | 10.15218/zjms.2020.001 |