Academic Journal
High expression of SGK1 in thrombosis of acute ST-segment elevation myocardial infarction: Based on proteomics analysis of intracoronary thrombosis
| العنوان: | High expression of SGK1 in thrombosis of acute ST-segment elevation myocardial infarction: Based on proteomics analysis of intracoronary thrombosis |
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| المؤلفون: | Mengyang Cai, Ningzhi Zhang, Dong Yang, Qibin Jiao, Peng Qu, Yuanyuan Zhang |
| المصدر: | Revista Portuguesa de Cardiologia, Vol 41, Iss 4, Pp 271-279 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Trombo, Enfarte do miocárdio com elevação do segmento ST, SGK1, Espectrometria de massa, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Introduction and objectives: Thrombosis is involved in the onset and progression of ST-segment elevation myocardial infarction (STEMI). The aim of this study was to explore the expression level of serum- and glucocorticoid-inducible kinase 1 (SGK1) in intracoronary thrombus and the relationship between them. Methods: We identified 30 patients who received treatment in the Affiliated Hospital of Hangzhou Normal University between May 2018 to May 2020 and who underwent thrombus aspiration and percutaneous coronary intervention for ST-segment-elevation myocardial infarction. Additionally, we selected 30 patients with normal coronary angiography for the control group. We analyzed thrombus protein expression profiling by combining tandem mass tag labeling, high-performance liquid chromatography fractionation and mass spectrometry quantification approach. Results: The differentially regulated protein profiles revealed the alteration of serine-threonine/tyrosine-protein kinase, which was upregulated significantly in the experimental group. We selected SGK1 downstream factor for validation and found that the expression of SGK1 in the thrombus of STEMI was significantly increased. Immunohistochemistry (IHC) showed significantly increased expression of SGK1 in the thrombus of STEMI patients compared with the control group (17.21±2.36 vs. 4.14±1.17%, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 0870-2551 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0870255122000233; https://doaj.org/toc/0870-2551 |
| DOI: | 10.1016/j.repc.2021.02.023 |
| URL الوصول: | https://doaj.org/article/f732e9c99a56498dab9a26feafc0a7d8 |
| رقم الانضمام: | edsdoj.f732e9c99a56498dab9a26feafc0a7d8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 08702551 |
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| DOI: | 10.1016/j.repc.2021.02.023 |