التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of In Vitro Cytotoxic Potential of Avarol towards Human Cancer Cell Lines and In Vivo Antitumor Activity in Solid Tumor Models |
| المؤلفون: |
Tatjana P. Stanojkovic, Marina Filimonova, Nadja Grozdanic, Slavica Petovic, Anna Shitova, Olga Soldatova, Alexander Filimonov, Jelena Vladic, Petr Shegay, Andrey Kaprin, Sergey Ivanov, Marina Nikitovic |
| المصدر: |
Molecules, Vol 27, Iss 24, p 9048 (2022) |
| بيانات النشر: |
MDPI AG, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
avarol, Dysidea avara, Ehrlich carcinoma, cervical cancer, cytotoxicity, Organic chemistry, QD241-441 |
| الوصف: |
The goal of this study was to determine the activity in vitro and in vivo of avarol, a sesquiterpene hydroquinone originating from the Dysidea avara sponge from the south Adriatic Sea, against different cancer cell lines and two types of mouse carcinoma. To investigate the in vitro cytotoxicity, a human cervix adenocarcinoma cell line (HeLa), human colon adenocarcinoma (LS174), human non-small-cell lung carcinoma (A549), and a normal human fetal lung fibroblast cell line (MRC-5) were used. The in vivo antitumor activity was investigated against two transplantable mouse tumors, the Ehrlich carcinoma (EC) and cervical cancer (CC-5). The effect of avarol on cancer cell survival, which was determined by the microculture tetrazolium test, confirmed a significant in vitro potency of avarol against the investigated cell lines, without selectivity towards MRC-5. The highest cytotoxicity was exhibited against HeLa cancer cells (10.22 ± 0.28 μg/mL). Moreover, potent antitumor activity against two tumor models was determined, as the intraperitoneal administration of avarol at a dose of 50 mg/kg resulted in a significant inhibition of tumor growth in mice. After three administrations of avarol, a 29% inhibition of the EC growth was achieved, while in the case of CC-5, a 36% inhibition of the tumor growth was achieved after the second administration of avarol. Therefore, the results indicate that this marine sesquiterpenoid hydroquinone could be a promising bioactive compound in the development of new anticancer medicine. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/27/24/9048; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules27249048 |
| URL الوصول: |
https://doaj.org/article/ddf7251b4bc54e29913fb5c94bbca59d |
| رقم الانضمام: |
edsdoj.f7251b4bc54e29913fb5c94bbca59d |
| قاعدة البيانات: |
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