Academic Journal
Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants
| العنوان: | Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants |
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| المؤلفون: | Philipp Schwenk, David J Sheerin, Jathish Ponnu, Anne-Marie Staudt, Klara L Lesch, Elisabeth Lichtenberg, Katalin F Medzihradszky, Ute Hoecker, Eva Klement, András Viczián, Andreas Hiltbrunner |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | light signalling, photomorphogenesis, phytochrome, CCR4-NOT complex, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Phytochromes are photoreceptors regulating growth and development in plants. Using the model plant Arabidopsis, we identified a novel signalling pathway downstream of the far-red light-sensing phytochrome, phyA, that depends on the highly conserved CCR4-NOT complex. CCR4-NOT is integral to RNA metabolism in yeast and animals, but its function in plants is largely unknown. NOT9B, an Arabidopsis homologue of human CNOT9, is a component of the CCR4-NOT complex, and acts as negative regulator of phyA-specific light signalling when bound to NOT1, the scaffold protein of the complex. Light-activated phyA interacts with and displaces NOT9B from NOT1, suggesting a potential mechanism for light signalling through CCR4-NOT. ARGONAUTE 1 and proteins involved in splicing associate with NOT9B and we show that NOT9B is required for specific phyA-dependent alternative splicing events. Furthermore, association with nuclear localised ARGONAUTE 1 raises the possibility that NOT9B and CCR4-NOT are involved in phyA-modulated gene expression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/63697; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.63697 |
| URL الوصول: | https://doaj.org/article/f71c1f35f033421c80f34e83009d1cc4 |
| رقم الانضمام: | edsdoj.f71c1f35f033421c80f34e83009d1cc4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.63697 |