التفاصيل البيبلوغرافية
| العنوان: |
Developing a medical device-grade T2 phantom optimized for myocardial T2 mapping by cardiovascular magnetic resonance |
| المؤلفون: |
Constantin-Cristian Topriceanu, Massimiliano Fornasiero, Han Seo, Matthew Webber, Kathryn E. Keenan, Karl F. Stupic, Rüdiger Bruehl, Bernd Ittermann, Kirsty Price, Louise McGrath, Wenjie Pang, Alun D. Hughes, Reza Nezafat, Peter Kellman, Iain Pierce, James C. Moon, Gabriella Captur |
| المصدر: |
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
T1 mapping, T2 mapping, Phantom, Quality control, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
Abstract Introduction A long T2 relaxation time can reflect oedema, and myocardial inflammation when combined with increased plasma troponin levels. Cardiovascular magnetic resonance (CMR) T2 mapping therefore has potential to provide a key diagnostic and prognostic biomarkers. However, T2 varies by scanner, software, and sequence, highlighting the need for standardization and for a quality assurance system for T2 mapping in CMR. Aim To fabricate and assess a phantom dedicated to the quality assurance of T2 mapping in CMR. Method A T2 mapping phantom was manufactured to contain 9 T1 and T2 (T1|T2) tubes to mimic clinically relevant native and post-contrast T2 in myocardium across the health to inflammation spectrum (i.e., 43–74 ms) and across both field strengths (1.5 and 3 T). We evaluated the phantom’s structural integrity, B 0 and B 1 uniformity using field maps, and temperature dependence. Baseline reference T1|T2 were measured using inversion recovery gradient echo and single-echo spin echo (SE) sequences respectively, both with long repetition times (10 s). Long-term reproducibility of T1|T2 was determined by repeated T1|T2 mapping of the phantom at baseline and at 12 months. Results The phantom embodies 9 internal agarose-containing T1|T2 tubes doped with nickel di-chloride (NiCl2) as the paramagnetic relaxation modifier to cover the clinically relevant spectrum of myocardial T2. The tubes are surrounded by an agarose-gel matrix which is doped with NiCl2 and packed with high-density polyethylene (HDPE) beads. All tubes at both field strengths, showed measurement errors up to ≤ 7.2 ms [ |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1532-429X |
| Relation: |
https://doaj.org/toc/1532-429X |
| DOI: |
10.1186/s12968-023-00926-z |
| URL الوصول: |
https://doaj.org/article/caef70cde30d4ae6831d1421826c142d |
| رقم الانضمام: |
edsdoj.f70cde30d4ae6831d1421826c142d |
| قاعدة البيانات: |
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