Academic Journal
Microscopic observation drug susceptibility assay (MODS) for early diagnosis of tuberculosis in children.
| العنوان: | Microscopic observation drug susceptibility assay (MODS) for early diagnosis of tuberculosis in children. |
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| المؤلفون: | Dang Thi Minh Ha, Nguyen Thi Ngoc Lan, Marcel Wolbers, Tran Ngoc Duong, Nguyen Dang Quang, Tran Thi Van Thinh, Le Thi Hong Ngoc, Nguyen Thi Ngoc Anh, Tran Van Quyet, Nguyen Thi Bich Tuyen, Vo Thi Ha, Jeremy Day, Hoang Thi Thanh Hang, Vo Sy Kiet, Nguyen Thi Nho, Dai Viet Hoa, Nguyen Huy Dung, Nguyen Huu Lan, Jeremy Farrar, Maxine Caws |
| المصدر: | PLoS ONE, Vol 4, Iss 12, p e8341 (2009) |
| بيانات النشر: | Public Library of Science (PLoS), 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | MODS is a novel liquid culture based technique that has been shown to be effective and rapid for early diagnosis of tuberculosis (TB). We evaluated the MODS assay for diagnosis of TB in children in Viet Nam. 217 consecutive samples including sputum (n = 132), gastric fluid (n = 50), CSF (n = 32) and pleural fluid (n = 3) collected from 96 children with suspected TB, were tested by smear, MODS and MGIT. When test results were aggregated by patient, the sensitivity and specificity of smear, MGIT and MODS against "clinical diagnosis" (confirmed and probable groups) as the gold standard were 28.2% and 100%, 42.3% and 100%, 39.7% and 94.4%, respectively. The sensitivity of MGIT and MODS was not significantly different in this analysis (P = 0.5), but MGIT was more sensitive than MODS when analysed on the sample level using a marginal model (P = 0.03). The median time to detection of MODS and MGIT were 8 days and 13 days, respectively, and the time to detection was significantly shorter for MODS in samples where both tests were positive (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC2791864?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0008341 |
| URL الوصول: | https://doaj.org/article/f6b81f580f2844c4b53cea14da02b59e |
| رقم الانضمام: | edsdoj.f6b81f580f2844c4b53cea14da02b59e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0008341 |