التفاصيل البيبلوغرافية
| العنوان: |
An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus |
| المؤلفون: |
Ursula Schulte-Wrede, Till Sörensen, Joachim R. Grün, Thomas Häupl, Heike Hirseland, Marta Steinbrich-Zöllner, Peihua Wu, Andreas Radbruch, Denis Poddubnyy, Joachim Sieper, Uta Syrbe, Andreas Grützkau |
| المصدر: |
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-10 (2018) |
| بيانات النشر: |
BMC, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: |
Ankylosing spondylitis, Etanercept, CD8+ NK cells, TNF-alpha blocker, Predictive biomarker, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: |
Abstract Background Therapeutic targeting of tumour necrosis factor (TNF)-α is highly effective in ankylosing spondylitis (AS) patients. However, since one-third of anti-TNF-treated AS patients do not show an adequate clinical response there is an urgent need for new biomarkers that would aid clinicians in their decision-making to select appropriate therapeutic options. Thus, the aim of this explorative study was to identify cell-based biomarkers in peripheral blood that could be used for a pre-treatment stratification of AS patients. Methods A high-dimensional, multi-parametric flow cytometric approach was applied to identify baseline predictors in 31 AS patients before treatment with the TNF blockers adalimumab (TNF-neutralisation) and etanercept (soluble TNF receptor). Results As the major result, the frequencies of natural killer (NK) cells, and in particular CD8-positive (CD8+) NK cell subsets, were most predictive for therapeutic outcome in AS patients. While an inverse correlation between classical CD56+/CD16+ NK cells and reduction of disease activity was observed, the CD8+ NK cell subset behaved in the opposite direction. At baseline, responders showed significantly increased frequencies of CD8+ NK cells compared with non-responders. Conclusions This is the first study demonstrating that the composition of the NK cell compartment has predictive power for prediction of therapeutic outcome for anti-TNF-α blockers, and we identified CD8+ NK cells as a potential new player in the TNF-α-driven chronic inflammatory immune response of AS. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1478-6362 |
| Relation: |
http://link.springer.com/article/10.1186/s13075-018-1692-y; https://doaj.org/toc/1478-6362 |
| DOI: |
10.1186/s13075-018-1692-y |
| URL الوصول: |
https://doaj.org/article/aeef69ba1ab44bfa92b5e78fc618f0e9 |
| رقم الانضمام: |
edsdoj.f69ba1ab44bfa92b5e78fc618f0e9 |
| قاعدة البيانات: |
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