Academic Journal
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations
| العنوان: | Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations |
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| المؤلفون: | Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg |
| المصدر: | Epigenetics, Vol 19, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Genetics |
| مصطلحات موضوعية: | Inflammation, C-reactive protein, methylation, epigenetics, EWAS, racial and ethnic diversity, Genetics, QH426-470 |
| الوصف: | Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflammation in disease is not completely understood. Methylation is an epigenetic modification in the DNA which plays a pivotal role in gene expression. In this study we evaluated differential DNA methylation patterns associated with blood CRP level to elucidate biological pathways and genetic regulatory mechanisms to improve the understanding of chronic inflammation. The racially and ethnically diverse participants in this study were included as 50% White, 41% Black or African American, 7% Hispanic or Latino/a, and 2% Native Hawaiian, Asian American, American Indian, or Alaska Native (total n = 13,433) individuals. We replicated 113 CpG sites from 87 unique loci, of which five were novel (CADM3, NALCN, NLRC5, ZNF792, and cg03282312), across a discovery set of 1,150 CpG sites associated with CRP level (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15592294 1559-2308 1559-2294 |
| Relation: | https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308 |
| DOI: | 10.1080/15592294.2024.2333668 |
| URL الوصول: | https://doaj.org/article/f6942193d47e4a7095b9b17d360571e0 |
| رقم الانضمام: | edsdoj.f6942193d47e4a7095b9b17d360571e0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15592294 15592308 |
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| DOI: | 10.1080/15592294.2024.2333668 |