Academic Journal
IMRT Reduces Acute Toxicity in Patients Treated With Preoperative Chemoradiation for Gastric Cancer
| العنوان: | IMRT Reduces Acute Toxicity in Patients Treated With Preoperative Chemoradiation for Gastric Cancer |
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| المؤلفون: | Shalini Moningi, MD, Jaffer A. Ajani, MD, Brian D. Badgwell, MD, Mariela B. Murphy, MD, Naruhiko Ikoma, MD, Paul F. Mansfield, MD, Jennifer C. Ho, MD, Yelin Suh, BS, Christopher Crane, MD, Joseph M. Herman, MD, Emma B. Holliday, MD, Eugene Koay, MD, PhD, Albert C. Koong, MD, PhD, Sunil Krishnan, MD, Bruce Minsky, MD, Grace Smith, MD, Cullen Taniguchi, MD, PhD, Prajnan Das, MD |
| المصدر: | Advances in Radiation Oncology, Vol 5, Iss 3, Pp 369-376 (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Purpose: Preoperative chemoradiation is being currently evaluated in 2 randomized international trials. However, chemoradiation for gastric cancer can be associated with relatively high rates of acute toxicity. We compared rates of toxicity, toxicity-related events, and oncologic outcomes in patients treated with intensity modulated radiation therapy (IMRT) and those treated with 3-dimensional conformal radiation therapy (3DCRT). Methods and Materials: We retrospectively reviewed records of 202 patients with consecutive gastric cancer treated with preoperative intent radiation therapy at our institution from 1998 to 2018. Patients with gastroesophageal junction involvement and those with metastatic disease were excluded. Eighty-two patients received 3DCRT, and 120 patients received IMRT. The median radiation dose was 45 Gy, and 99% received concurrent chemotherapy. Results: There were no significant differences between the 3DCRT and IMRT groups regarding sex, race, histology, tumor location, histology, or nodal stage. The rate of grade 3 to 4 acute toxicity was significantly lower in patients treated with IMRT compared with 3DCRT (49% vs 70%, P = .004). The composite rate of toxicity-related events (hospitalization, feeding tube use, intravenous rehydration, or radiation therapy breaks) was also significantly lower in patients treated with IMRT compared with 3DCRT (56% vs 85%, P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-1094 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452109419301678; https://doaj.org/toc/2452-1094 |
| DOI: | 10.1016/j.adro.2019.11.003 |
| URL الوصول: | https://doaj.org/article/f658dbf7470c4d9c839db79557e79626 |
| رقم الانضمام: | edsdoj.f658dbf7470c4d9c839db79557e79626 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24521094 |
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| DOI: | 10.1016/j.adro.2019.11.003 |