Academic Journal
The effect of endurance training and vitamin C consumption in the conditions of air pollution on the expression of apoptotic proteins BAX and Bcl-2 in the brain of male Wistar rats
| العنوان: | The effect of endurance training and vitamin C consumption in the conditions of air pollution on the expression of apoptotic proteins BAX and Bcl-2 in the brain of male Wistar rats |
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| المؤلفون: | Sayyed Saeed Vaezi, Mohsen Salesi, Farhad Daryanoosh, Mohammad Hemati Nafar |
| المصدر: | مجله علوم پزشکی فیض (پیوسته), Vol 27, Iss 2, Pp 144-153 (2023) |
| بيانات النشر: | Kashan University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | endurance training, vitamin c, bax protein, bcl-2 protein, Medicine |
| الوصف: | Background: Factors such as exercises training and taking antioxidant supplements can moderate or increase apoptosis. Therefore, this present study aimed to the effect of endurance training and vitamin C consumption in the conditions of air pollution on the expression of apoptotic proteins BAX and Bcl-2 in the brain of male Wistar rats. Materials and Methods: In this experimental study, 30 Wistar rats were randomly divided into five groups: 1) polluted air control, 2) supplement, 3) training, 4) training+supplement, and 5) healthy air control .Rats trained in polluted air were maintained in a special chamber to simulate polluted air and performed endurance training protocol .Vitamin C supplement groups received the supplement at a dose of 20 mg/kg. Data analysis was done through One-Way-ANOVA and Tukey's post-hoc tests in SPSS version 26 software. Results: There is a significant difference in BAX and BCL-2 protein gene expression between the groups (P≤0.0001). This significant difference was the increase in BAX protein expression in the training+supplement group as well as the healthy air control group compared to other groups (P≤0.05). In the training and supplement groups were seen a decrease in BCL-2 protein expression compared to the control group (polluted and healthy) (P≤0.05). Conclusion: Considering the increase in BAX and decrease in BCL-2 expression, it is possible that training in polluted air can lead to cell damage related to apoptosis. Also, the use of vitamin C supplement alone or together with training cannot modulate the apoptosis of brain cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Persian |
| تدمد: | 3060-5806 3060-5814 |
| Relation: | http://feyz.kaums.ac.ir/article-1-4749-en.pdf; https://doaj.org/toc/3060-5806; https://doaj.org/toc/3060-5814 |
| URL الوصول: | https://doaj.org/article/f6443f30cca24d0586283faa98451021 |
| رقم الانضمام: | edsdoj.f6443f30cca24d0586283faa98451021 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 30605806 30605814 |
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