التفاصيل البيبلوغرافية
| العنوان: |
Predictive value of plasma proenkephalin and neutrophil gelatinase-associated lipocalin in acute kidney injury and mortality in cardiogenic shock |
| المؤلفون: |
Toni Jäntti, Tuukka Tarvasmäki, Veli-Pekka Harjola, Kari Pulkki, Heidi Turkia, Tuija Sabell, Heli Tolppanen, Raija Jurkko, Mari Hongisto, Anu Kataja, Alessandro Sionis, Jose Silva-Cardoso, Marek Banaszewski, Salvatore DiSomma, Alexandre Mebazaa, Mikko Haapio, Johan Lassus, for the CardShock investigators |
| المصدر: |
Annals of Intensive Care, Vol 11, Iss 1, Pp 1-15 (2021) |
| بيانات النشر: |
SpringerOpen, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Medical emergencies. Critical care. Intensive care. First aid |
| مصطلحات موضوعية: |
Cardiogenic shock, Acute kidney injury, AKI, Mortality, Prognosis, Proenkephalin, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9 |
| الوصف: |
Abstract Background Acute kidney injury (AKI) is a frequent form of organ injury in cardiogenic shock. However, data on AKI markers such as plasma proenkephalin (P-PENK) and neutrophil gelatinase-associated lipocalin (P-NGAL) in cardiogenic shock populations are lacking. The objective of this study was to assess the ability of P-PENK and P-NGAL to predict acute kidney injury and mortality in cardiogenic shock. Results P-PENK and P-NGAL were measured at different time points between baseline and 48 h in 154 patients from the prospective CardShock study. The outcomes assessed were AKI defined by an increase in creatinine within 48 h and all-cause 90-day mortality. Mean age was 66 years and 26% were women. Baseline levels of P-PENK and P-NGAL (median [interquartile range]) were 99 (71–150) pmol/mL and 138 (84–214) ng/mL. P-PENK > 84.8 pmol/mL and P-NGAL > 104 ng/mL at baseline were identified as optimal cut-offs for AKI prediction and independently associated with AKI (adjusted HRs 2.2 [95% CI 1.1–4.4, p = 0.03] and 2.8 [95% CI 1.2–6.5, p = 0.01], respectively). P-PENK and P-NGAL levels at baseline were also associated with 90-day mortality. For patients with oliguria 6 h before study enrollment, 90-day mortality differed significantly between patients with low and high P-PENK/P-NGAL at baseline (5% vs. 68%, p 105.7 pmol/L and P-NGAL24h > 151 ng/mL had unadjusted hazard ratios of 5.6 (95% CI 3.1–10.7, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2110-5820 |
| Relation: |
https://doaj.org/toc/2110-5820 |
| DOI: |
10.1186/s13613-021-00814-8 |
| URL الوصول: |
https://doaj.org/article/f5fab8575e374934a408aecf1bb61d22 |
| رقم الانضمام: |
edsdoj.f5fab8575e374934a408aecf1bb61d22 |
| قاعدة البيانات: |
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