التفاصيل البيبلوغرافية
| العنوان: |
Specific Urinary Metabolites in Malignant Melanoma |
| المؤلفون: |
Marcela Valko-Rokytovská, Beáta Hubková, Anna Birková, Jana Mašlanková, Marek Stupák, Marianna Zábavníková, Beáta Čižmárová, Mária Mareková |
| المصدر: |
Medicina, Vol 55, Iss 5, p 145 (2019) |
| بيانات النشر: |
MDPI AG, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Medicine (General) |
| مصطلحات موضوعية: |
HPLC, urine, malignant melanoma, metabolite, 5,6-dihydroxyindole-2-carboxylic acid, vanilmandelic acid, homovanilic acid, tryptophan, 5-hydroxyindole-3-acetic acid, indoxyl sulphate, Medicine (General), R5-920 |
| الوصف: |
Background and objectives: Melanin, which has a confirmed role in melanoma cell behaviour, is formed in the process of melanogenesis and is synthesized from tryptophan, L-tyrosine and their metabolites. All these metabolites are easily detectable by chromatography in urine. Materials and Methods: Urine samples of 133 individuals (82 malignant melanoma patients and 51 healthy controls) were analysed by reversed-phase high-performance liquid chromatography (RP-HPLC). The diagnosis of malignant melanoma was confirmed histologically. Results: Chromatograms of melanoma patients showed increased levels of 5,6-dihydroxyindole-2-carboxylic acid, vanilmandelic acid, homovanilic acid, tryptophan, 5-hydroxyindole-3-acetic acid, and indoxyl sulphate compared to healthy controls. Concentration of indoxyl sulphate, homovanilic acid and tryptophan were significantly increased even in the low clinical stage 0 of the disease (indoxyl sulphate, homovanilic acid and tryptophan in patients with clinical stage 0 vs. controls expressed as medium/ interquartile range in µmol/mmol creatinine: 28.37/15.30 vs. 5.00/6.91; 47.97/33.08 vs. 7.33/21.25; and 16.38/15.98 vs. 3.46/6.22, respectively). Conclusions: HPLC detection of metabolites of L-tyrosine and tryptophan in the urine of melanoma patients may play a significant role in diagnostics as well as a therapeutic strategy of melanoma cancer. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1010-660X |
| Relation: |
https://www.mdpi.com/1010-660X/55/5/145; https://doaj.org/toc/1010-660X |
| DOI: |
10.3390/medicina55050145 |
| URL الوصول: |
https://doaj.org/article/f597d6f7bc514deb846556bd61180821 |
| رقم الانضمام: |
edsdoj.f597d6f7bc514deb846556bd61180821 |
| قاعدة البيانات: |
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