Academic Journal
Topical application of activity-based probes for visualization of brain tumor tissue.
| العنوان: | Topical application of activity-based probes for visualization of brain tumor tissue. |
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| المؤلفون: | Jennifer L Cutter, Nathan T Cohen, Jing Wang, Andrew E Sloan, Alan R Cohen, Ashok Panneerselvam, Mark Schluchter, Galia Blum, Matthew Bogyo, James P Basilion |
| المصدر: | PLoS ONE, Vol 7, Iss 3, p e33060 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Several investigators have shown the utility of systemically delivered optical imaging probes to image tumors in small animal models of cancer. Here we demonstrate an innovative method for imaging tumors and tumor margins during surgery. Specifically, we show that optical imaging probes topically applied to tumors and surrounding normal tissue rapidly differentiate between tissues. In contrast to systemic delivery of optical imaging probes which label tumors uniformly over time, topical probe application results in rapid and robust probe activation that is detectable as early as 5 minutes following application. Importantly, labeling is primarily associated with peri-tumor spaces. This methodology provides a means for rapid visualization of tumor and potentially infiltrating tumor cells and has potential applications for directed surgical excision of tumor tissues. Furthermore, this technology could find use in surgical resections for any tumors having differential regulation of cysteine cathepsin activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3302795?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0033060 |
| URL الوصول: | https://doaj.org/article/f52fbf6f91664afb971aedd78f65254a |
| رقم الانضمام: | edsdoj.f52fbf6f91664afb971aedd78f65254a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0033060 |