Academic Journal
A large family of antivirulence regulators modulates the effects of transcriptional activators in Gram-negative pathogenic bacteria.
| العنوان: | A large family of antivirulence regulators modulates the effects of transcriptional activators in Gram-negative pathogenic bacteria. |
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| المؤلفون: | Araceli E Santiago, Fernando Ruiz-Perez, Noah Y Jo, Vidhya Vijayakumar, Mei Q Gong, James P Nataro |
| المصدر: | PLoS Pathogens, Vol 10, Iss 5, p e1004153 (2014) |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | We have reported that transcription of a hypothetical small open reading frame (orf60) in enteroaggregative E. coli (EAEC) strain 042 is impaired after mutation of aggR, which encodes a global virulence activator. We have also reported that the cryptic orf60 locus was linked to protection against EAEC diarrhea in two epidemiologic studies. Here, we report that the orf60 product acts as a negative regulator of aggR itself. The orf60 protein product lacks homology to known repressors, but displays 44-100% similarity to at least fifty previously undescribed small ( |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| Relation: | http://europepmc.org/articles/PMC4038620?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
| DOI: | 10.1371/journal.ppat.1004153 |
| URL الوصول: | https://doaj.org/article/f503b6823f59484591f05391da765bcb |
| رقم الانضمام: | edsdoj.f503b6823f59484591f05391da765bcb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1004153 |