Academic Journal
Evaluation of the Antineoplastic Activity of L-rhamnose in vitro. A Comparison with 2-deoxyglucose
| العنوان: | Evaluation of the Antineoplastic Activity of L-rhamnose in vitro. A Comparison with 2-deoxyglucose |
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| المؤلفون: | Pavel Tomšík, Alena Stoklasová, Stanislav Mičuda, Mohamed Niang, Petr Šuba, Jiří Knížek, Martina Řezáčová |
| المصدر: | Acta Medica, Vol 51, Iss 2, Pp 113-119 (2008) |
| بيانات النشر: | Karolinum Press, 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | L-rhamnose, 2-deoxyglucose, DNA synthesis, Protein synthesis, Apoptosis, Tumor, Medicine |
| الوصف: | The effect of unsubstituted deoxyhexoses, 2-deoxy-D-glucose (2-DG) and L-fucose, on tumor cells has been reported in several papers throughout the last decades. That of a similar deoxysugar, L-rhamnose, which is synthesized in bacteria and plants but not in animal cells, has until today not been explored. In the present study, we examined the effect of L-rhamnose on DNA and protein synthesis, growth and the potential induction of apoptosis of tumor cells in vitro. Using 2-DG for comparison, we studied the effect of L-rhamnose in concentrations up to 20 (32 resp.) mmol/l on the initial velocity of the incorporation of labeled precursors of DNA and proteins in short term cultures of both mouse Ehrlich ascites tumor (EAT) and human HL-60 cells in vitro, and further, on cell proliferation and apoptosis induction in HL-60 cells. Neither cytotoxic nor cytostatic effects of L-rhamnose were observed with the exception of slightly pronounced inhibition of DNA synthesis in EAT cells. From the lacking inhibition of the protein synthesis it can be considered that L-rhamnose does not interfere with energy metabolism, at least not in a similar manner as 2-DG. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 18059694 1211-4286 1805-9694 |
| Relation: | https://actamedica.lfhk.cuni.cz/51/2/0113/; https://doaj.org/toc/1211-4286; https://doaj.org/toc/1805-9694 |
| DOI: | 10.14712/18059694.2017.12 |
| URL الوصول: | https://doaj.org/article/f500ca8a568c48c39a763fd3031abe70 |
| رقم الانضمام: | edsdoj.f500ca8a568c48c39a763fd3031abe70 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18059694 12114286 |
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| DOI: | 10.14712/18059694.2017.12 |