Academic Journal
Green synthesised CuNPs using Alhagi maurorum extract and its ability to amelioration of Mycoplasma pneumoniae infected pneumonia mice model
| العنوان: | Green synthesised CuNPs using Alhagi maurorum extract and its ability to amelioration of Mycoplasma pneumoniae infected pneumonia mice model |
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| المؤلفون: | Tian Liyuan, Zhang Lijun, Hou Wei, Jia Meixuan, Zhang Man, Yan Zhihui, Li Qingtao, Qian Xiaona, Wang Qian, Tian Jiangling, You Dianping, Wang Yakun |
| المصدر: | Journal of Experimental Nanoscience, Vol 17, Iss 1, Pp 585-598 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Chemical technology |
| مصطلحات موضوعية: | Alhagi maurorum, copper nanoparticles, Mycoplasma pneumonia, mouse model, inflammatory cytokines, Materials of engineering and construction. Mechanics of materials, TA401-492, Chemical technology, TP1-1185 |
| الوصف: | In this study, copper nanoparticles were synthesised according to green chemistry rules using the aqueous extract of Alhagi maurorum. The green-synthesised CuNPs were characterised using different techniques such as EDX, FE-SEM, XRD and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with a size of 42.68–68.87 nm. In vivo, the Mycoplasma pneumonia injection was applied for inducing pneumonia in the BALB/c mice, also the treatment was with CuNPs. The serum parameters such as inflammatory mediators (IL-6, TNF-α, IL-8, TGF and IL-1), total cell counts, and total protein content levels were evaluated. CuNPs regulated the levels of the inflammatory mediators in the infected mice. The cellular arrangements at the histopathological images were ameliorated with the administration of CuNPs. At the antioxidant test, the CuNPs and BHT removed 50% of free radicals at the concentrations of 181 and 110 µg/ml. In conclusion, the results revealed the ameliorative property of CuNPs green-formulated by A. maurorum aqueous extract on M. pneumoniae infected pneumonia mice model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 17458080 1745-8099 1745-8080 |
| Relation: | https://doaj.org/toc/1745-8080; https://doaj.org/toc/1745-8099 |
| DOI: | 10.1080/17458080.2022.2104451 |
| URL الوصول: | https://doaj.org/article/f48062a4b4a24e0ea527d5ad9e4bf3ac |
| رقم الانضمام: | edsdoj.f48062a4b4a24e0ea527d5ad9e4bf3ac |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 17458080 17458099 |
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| DOI: | 10.1080/17458080.2022.2104451 |