التفاصيل البيبلوغرافية
| العنوان: |
Characteristics of New Peptides GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT as Inhibitors of Enzymes Involved in Metabolic Syndrome and Antimicrobial Potential |
| المؤلفون: |
Urszula Złotek, Anna Jakubczyk, Kamila Rybczyńska-Tkaczyk, Paula Ćwiek, Barbara Baraniak, Sławomir Lewicki |
| المصدر: |
Molecules, Vol 25, Iss 11, p 2492 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
peptides, inhibitory, metabolic syndrome, cytotoxic properties, antimicrobial activity, Organic chemistry, QD241-441 |
| الوصف: |
The aim of this study was to determine the cytotoxic properties, influence on enzyme activity involved in metabolic syndrome, and antimicrobial activity of synthetic peptides with GQLGEHGGAGMG, GEHGGAGMGGGQFQPV, EQGFLPGPEESGR, RLARAGLAQ, YGNPVGGVGH, and GNPVGGVGHGTTGT sequences. Peptides have no cytotoxic effect on cells. The highest inhibitory effect on angiotensin converting enzyme I was noted for peptide GT-14 (IC50 = 525.63 µg/mL). None of the tested peptides had an influence on α-glucosidase. The highest α-amylase and lipase inhibitory activity was noted for GG-12 (IC50 = 56.72 and 60.62 µg/mL, respectively). The highest lipoxidase inhibitory activity was determined for peptide ER-13 (IC50 = 84.35 µg/mL). Peptide RQ-9 was characterized by the highest COX inhibitory activity (0.31 and 4.77 µg/mL for COX-1 and COX-2, respectively). Only peptide RQ-9 inhibited S. enteritidis ATCC 4931 growth (42–48%) in all tested concentrations (15.62–250 mg/mL). |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/25/11/2492; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules25112492 |
| URL الوصول: |
https://doaj.org/article/f40cf41d19a6410ba1bc668e3b7e7acd |
| رقم الانضمام: |
edsdoj.f40cf41d19a6410ba1bc668e3b7e7acd |
| قاعدة البيانات: |
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