Academic Journal
Comparison of centrifugal-membrane hybrid plasmapheresis and centrifugation therapeutic plasma exchange in hyperlipidemia
| العنوان: | Comparison of centrifugal-membrane hybrid plasmapheresis and centrifugation therapeutic plasma exchange in hyperlipidemia |
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| المؤلفون: | ZHANG Bin, WU Chunxi, ZHOU Yumeng, ZHOU Fang, YI Zhongmei |
| المصدر: | Zhongguo shuxue zazhi, Vol 37, Iss 12, Pp 1365-1370 (2024) |
| بيانات النشر: | Institute of Blood Transfusion of Chinese Academy of Medical Sciences, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Medicine |
| مصطلحات موضوعية: | centrifugal-membrane hybrid plasmapheresis (cmhp), therapeutic plasma exchange (tpe), centrifugation, hyperlipidemia, Diseases of the blood and blood-forming organs, RC633-647.5, Medicine |
| الوصف: | [Objective] To establish a new centrifugal-membrane hybrid plasmapheresis (CMHP) model, and observe its clinical efficacy, safety and advantages in the treatment of hyperlipidemia by comparing with centrifugation therapeutic plasma exchange (cTPE). [Methods] A retrospective analysis was performed on 47 patients with hyperlipidemia treated in our department from August 2021 to September 2023, with a total of 60 treatments. They were divided into two groups: CMHP group with 37 patients and 46 treatments; cTPE group included 10 patients with 14 treatments. In the CMHP group, the plasma was separated by a blood cell separator and the plasma components were separated by a two-stage membrane plasma component separator. In the cTPE group, the plasma was separated by a blood cell separator for therapeutic plasma exchange. The clinical efficacy, safety and advantages of the two groups were compared. [Results] The reduction ratios of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) before and after treatment in CMHP group were 68.56%[59.81%, 73.42%], 65.80%[55.55%, 75.98%] and 46.57%[36.02%, 54.83%] and 66.67%[43.48%, 76.24%] respectively, with statistically significant difference (P0.05). At the same time, the cTPE group required 1 520.00 mL[1 462.50 mL, 2 000.00 mL] plasma input, while the CMHP group achieved zero blood input. The adverse reaction ratio was 6.52%(3/46) in CMHP group and 7.14%(1/14) in cTPE group, and the difference was not statistically significant (P>0.05). [Conclusion] Compared with cTPE, CMHP can better reduce blood lipid levels without any blood products, avoid the spread of blood infectious diseases, and have a low incidence of adverse reactions, so it has a good clinical application prospect. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1004-549X 1004-549x |
| Relation: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2024.12.004&lang=en; https://doaj.org/toc/1004-549X |
| DOI: | 10.13303/j.cjbt.issn.1004-549x.2024.12.004&lang=en |
| DOI: | 10.13303/j.cjbt.issn.1004-549x.2024.12.004 |
| URL الوصول: | https://doaj.org/article/f394d8ab78604e85addee2388bcc42ab |
| رقم الانضمام: | edsdoj.f394d8ab78604e85addee2388bcc42ab |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 1004549X 1004549x |
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| DOI: | 10.13303/j.cjbt.issn.1004-549x.2024.12.004&lang=en |