التفاصيل البيبلوغرافية
| العنوان: |
Coexistence of GLIM-defined malnutrition and sarcopenia have negative effect on the clinical outcomes in the elderly gastric cancer patients after radical gastrectomy |
| المؤلفون: |
Wei-Zhe Chen, Xian-Zhong Zhang, Feng-Min Zhang, Ding-Ye Yu, Wen-Hao Chen, Feng Lin, Qian-Tong Dong, Cheng-Le Zhuang, Zhen Yu |
| المصدر: |
Frontiers in Nutrition, Vol 9 (2022) |
| بيانات النشر: |
Frontiers Media S.A., 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: |
elderly patients, gastric cancer, GLIM, malnutrition, sarcopenia, Nutrition. Foods and food supply, TX341-641 |
| الوصف: |
BackgroundMalnutrition and sarcopenia are common in elderly gastric cancer patients, which are also interrelated and affect each other. We aimed to determine the characteristics of coexistence of malnutrition and sarcopenia in the elderly gastric cancer patients and investigate the predictive roles of malnutrition and sarcopenia on clinical outcomes.MethodsBetween 2014 and 2019, a total of 742 elderly gastric cancer patients were enrolled. Malnutrition and sarcopenia were diagnosed according to the most recent diagnostic criteria. Patients were divided into four groups according to presence of these two symptoms. Clinical characteristics, short- and long-term outcomes were compared among four groups. The independent risk factors for complications and survival were evaluated using univariate and multivariate analyses.ResultsOf all patients, 34.8% were diagnosed with malnutrition and 34.0% were diagnosed with sarcopenia. Patients with both malnutrition and sarcopenia had the highest rate of total (P < 0.001), surgical (P = 0.003), and medical complications (P = 0.025), and the highest postoperative hospital stays (P < 0.001) and hospitalization costs (P < 0.001). They also had the worst overall survival (P < 0.0001) and disease-free survival (P < 0.0001). Sarcopenia and Charlson Comorbidity Index (≥2) were independent risk factors for total complications. Hypoalbuminemia and malnutrition were non-tumor-related independent risk factors for overall survival and disease-free survival.ConclusionsMalnutrition and sarcopenia had superimposed negative effects on elderly gastric cancer patients. Preoperative geriatric evaluation including screening for malnutrition and sarcopenia are recommended for all elderly gastric cancer patients for accurate treatment strategy. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2296-861X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnut.2022.960670/full; https://doaj.org/toc/2296-861X |
| DOI: |
10.3389/fnut.2022.960670 |
| URL الوصول: |
https://doaj.org/article/f316d46cf5a045cf9480c5200f2495d5 |
| رقم الانضمام: |
edsdoj.f316d46cf5a045cf9480c5200f2495d5 |
| قاعدة البيانات: |
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