Academic Journal
Role of Brain Biomarkers S-100-Beta and Neuron-Specific Enolase for Detection and Follow-Up of Hepatic Encephalopathy in Cirrhosis before, during and after Treatment with L-Ornithine-L-Aspartate
| العنوان: | Role of Brain Biomarkers S-100-Beta and Neuron-Specific Enolase for Detection and Follow-Up of Hepatic Encephalopathy in Cirrhosis before, during and after Treatment with L-Ornithine-L-Aspartate |
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| المؤلفون: | Hendrik Strebel, Bernhard Haller, Maximilian Sohn, Wolfgang Schepp, Felix Gundling |
| المصدر: | GE: Portuguese Journal of Gastroenterology, Pp 1-13 (2020) |
| بيانات النشر: | Karger Publishers, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | cirrhosis, critical flicker frequency, hepatic encephalopathy, l-ornithine-l-aspartate, neuron-specific enolase, pse-testing, s-100-beta, west-haven criteria, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Introduction: Hepatic encephalopathy (HE), in the context of liver cirrhosis, seems to result from low-grade cerebral edema of the astrocytes. Serum brain biomarkers S-100-beta und neuron-specific enolase (NSE) are often elevated in brain injury. We hypothesized that neuromarkers S-100-beta and NSE can be used in the diagnosis of HE, compared with standardized diagnostic tools. Material and Methods: A prospective non-randomized intervention study was performed using L-ornithine-L-aspartate (LOLA) for HE treatment. Primary endpoint was the evaluation of neuromarkers S-100-beta and NSE for detection and diagnosis of follow-up of HE. As secondary endpoints, the efficacy of LOLA on the course of HE and the diagnostic role of Portosystemic-Encephalopathy-Syndrome score (PHES) and critical flicker frequency (CFF) were analyzed. For diagnosis of covert (CHE) and overt (OHE) HE, West-Haven criteria (WHC), PHES and CFF were assessed at study entry. LOLA was applied (20 g i.v.) for 6 days. At the end of the study, HE evaluation was repeated. S-100-beta, NSE and ammonia were assessed in each patient before, during and after therapy with LOLA. Results: 30 patients were included. At study entry, CHE was diagnosed in 50% and OHE in 50% of all subjects. A total of 25 participants completed the study. After LOLA therapy, deterioration of HE occurred in |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2341-4545 2387-1954 |
| Relation: | https://www.karger.com/Article/FullText/507225; https://doaj.org/toc/2341-4545; https://doaj.org/toc/2387-1954 |
| DOI: | 10.1159/000507225 |
| URL الوصول: | https://doaj.org/article/f2dc74c1ef574c3c954c766aa5d6a275 |
| رقم الانضمام: | edsdoj.f2dc74c1ef574c3c954c766aa5d6a275 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23414545 23871954 |
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| DOI: | 10.1159/000507225 |