Academic Journal
Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study
| العنوان: | Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study |
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| المؤلفون: | Whitney E. Harrington, Winnie Yeung, Ingrid A. Beck, Fred D. Mast, John Houck, Sheila Styrchak, Leslie R. Miller, Song Li, Micaela Haglund, Yonghou Jiang, Blair Armistead, Jackson Wallner, Tina Nguyen, Daisy Ko, Samantha Hardy, Alyssa Oldroyd, Ana Gervassi, John D. Aitchison, Lisa M. Frenkel |
| المصدر: | PLoS ONE, Vol 17, Iss 9 (2022) |
| بيانات النشر: | Public Library of Science (PLoS), 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Background Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. Methods To identify SARS-CoV-2 infections 553 seronegative individuals were prospectively followed for 52 weeks. From 4/2020-7/2021, participants submitted weekly self-collected nasal swabs for rtPCR and completed symptom and exposure surveys. Results Incident SARS2-CoV-2 infections were identified in 9/553 (1.6%) participants. Comparisons of SARS2-CoV-2(+) to SARS2-CoV-2(-) participants revealed significantly more close contacts outside the household (median: 5 versus 3; p = 0.005). The incidence of infection was higher among unvaccinated/partially vaccinated than among fully vaccinated participants (9/7,679 versus 0/6,845 person-weeks; p = 0.004). At notification of positive test result, eight cases were symptomatic and one pre-symptomatic. Conclusions These data suggest that weekly SARS2-CoV2 surveillance by rtPCR did not efficiently detect pre-symptomatic infections in unvaccinated participants. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512209/?tool=EBI; https://doaj.org/toc/1932-6203 |
| URL الوصول: | https://doaj.org/article/eef1ebf3b2da434aa54c155bced8b70e |
| رقم الانضمام: | edsdoj.f1ebf3b2da434aa54c155bced8b70e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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