Academic Journal
Development and Application of Catheter Electrodes for Rat Airway High-Voltage Pulsed Electric Field Ablation
| العنوان: | Development and Application of Catheter Electrodes for Rat Airway High-Voltage Pulsed Electric Field Ablation |
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| المؤلفون: | Nana ZHANG, Yirong AN, Jiawei TIAN, Xuan HAN, Shen’ao QU, Haoze LENG, Shiran TAO, Fenggang REN, Yi LYU, Haoyang ZHU |
| المصدر: | Zhongguo yiliao qixie zazhi, Vol 48, Iss 5, Pp 568-572 (2024) |
| بيانات النشر: | Editorial Office of Chinese Journal of Medical Instrumentation, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Computer applications to medicine. Medical informatics LCC:Medical technology |
| مصطلحات موضوعية: | high-voltage pulsed electric field, catheter electrode, airway ablation, chronic obstructive pulmonary disease (copd), Computer applications to medicine. Medical informatics, R858-859.7, Medical technology, R855-855.5 |
| الوصف: | High-voltage pulsed electric field (HV-PEF) ablation technology has demonstrated promising applications in the clinical treatment of chronic obstructive pulmonary disease (COPD). However, its use has been limited to exploratory applications in a small number of cases, and the underlying mechanisms remain largely undefined. To facilitate broader clinical implementation, comprehensive molecular mechanism studies via extensive animal experimentation are essential. Rats, due to their ease of modeling COPD and the availability of comprehensive molecular reagents, serve as an optimal model for such studies. Consequently, the development of electrodes specifically designed for HV-PEF respiratory ablation in SD rats is of significant importance. In this study, we meticulously examined the anatomical structure of rat airways and investigated various equipment parameters, including material composition, rigidity, diameter, electrode ring dimensions, spacing between positive and negative poles, insulation coating for the catheters, welding techniques between the guidewire and electrode ring, and the design of vent holes in the catheter. Based on these considerations, we fabricated PVC ablation electrode catheters with integrated ventilation functionality. Subsequently, we employed finite element simulation to estimate the field strengths that could be applied by these electrodes. The simulation results were then validated in normal rats to assess the electrical safety and efficacy of the electrodes. These findings laid the groundwork for further investigation into the mechanisms of HV-PEF treatment for COPD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1671-7104 |
| Relation: | https://doaj.org/toc/1671-7104 |
| DOI: | 10.12455/j.issn.1671-7104.240146 |
| URL الوصول: | https://doaj.org/article/f1eb5943f3484f9cab04cf5dbc495986 |
| رقم الانضمام: | edsdoj.f1eb5943f3484f9cab04cf5dbc495986 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 16717104 |
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| DOI: | 10.12455/j.issn.1671-7104.240146 |