التفاصيل البيبلوغرافية
| العنوان: |
Extracts of Brocchia cinerea (Delile) Vis Exhibit In Vivo Wound Healing, Anti-Inflammatory and Analgesic Activities, and Other In Vitro Therapeutic Effects |
| المؤلفون: |
Abdelkrim Agour, Ibrahim Mssillou, Azeddin El Barnossi, Mohamed Chebaibi, Amina Bari, Manal Abudawood, Yazeed A. Al-Sheikh, Mohammed Bourhia, John P. Giesy, Mourad A. M. Aboul-Soud, Badiaa Lyoussi, Elhoussine Derwich |
| المصدر: |
Life, Vol 13, Iss 3, p 776 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
analgesic activity, antibacterial, antioxidant, traditional medicine, wound healing, Science |
| الوصف: |
The plant Brocchia cinerea (Delile) (B. cinerea) has many uses in traditional pharmacology. Aqueous (BCAE) and ethanolic extracts (BCEE) obtained from the aerial parts can be used as an alternative to some synthetic drugs. In vitro, DPPH, FRAP and TAC are three tests used to measure antioxidant efficacy. Antibacterial activities were determined against one Gram positive and two Gram negative strains of bacteria. The analgesic power was evaluated in vivo using the abdominal contortion model in mice, while carrageenan-induced edema in rats was the model chosen for the anti-inflammatory test; wound healing was evaluated in an experimental second degree burn model. The results of the phytochemical analysis showed that BCEE had the greatest content of polyphenols (21.06 mg AGE/g extract), flavonoids (10.43 mg QE/g extract) and tannins (24.05 mg TAE/g extract). HPLC-DAD reveals the high content of gallic acid, quercetin and caffeic acid in extracts. BCEE has a strong antiradical potency against DPPH (IC50 = 0.14 mg/mL) and a medium iron reducing activity (EC50 = 0.24 mg/mL), while BCAE inhibited the growth of the antibiotic resistant bacterium, P. aeruginosa (MIC = 10 mg/mL). BCAE also exhibited significant pharmacological effects and analgesic efficacy (55.81% inhibition 55.64% for the standard used) and the re-epithelialization of wounds, with 96.91% against 98.60% for the standard. These results confirm the validity of the traditional applications of this plant and its potential as a model to develop analogous drugs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2075-1729 |
| Relation: |
https://www.mdpi.com/2075-1729/13/3/776; https://doaj.org/toc/2075-1729 |
| DOI: |
10.3390/life13030776 |
| URL الوصول: |
https://doaj.org/article/f1829a29bf6040eaab6071e4e2329788 |
| رقم الانضمام: |
edsdoj.f1829a29bf6040eaab6071e4e2329788 |
| قاعدة البيانات: |
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