التفاصيل البيبلوغرافية
| العنوان: |
The detrimental effect of donor-specific antibodies is irrespective of its level in highly-immunized living donor kidney transplant recipients: A case-control series |
| المؤلفون: |
T. Tramper, D. L. Roelen, S. H. Brand-Schaaf, J. A. Kal-van Gestel, M. M. L. Kho, M. E. J. Reinders, J. I. Roodnat, J. van de Wetering, M. G. H. Betjes, A. E. de Weerd |
| المصدر: |
Frontiers in Immunology, Vol 13 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
kidney transplantation, donor-specific antibodies, antibody-mediated (ABMR), panel-reactive antibodies, graft survival, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
BackgroundThe impact of donor-specific antibodies (DSA) in (highly-) immunized living donor kidney transplant recipients is reported differentially in various patient cohorts.MethodsWe have performed a retrospective analysis of all consecutive HLA-incompatible living donor kidney transplant recipients in our center between 2010-2019. Recipients who underwent plasmafiltration for a positive CDC-crossmatch were excluded. For each DSA+ recipient (DSA+), one immunized recipient without DSA (pPRA+) and two non-immunized recipients (pPRA-) were included. Patient and graft survival were analyzed and a subgroup analysis of DSA+ recipients was performed.ResultsFor 63 DSA+ recipients, 63 PRA+ and 126 PRA- recipients were included. 26 (41%) had class I, 24 (38%) class II and 13 (21%) combined HLA class I and II DSA. Death-censored graft survival was inferior in DSA+ recipients compared to pPRA+ (HR 2.38 [95% CI 1.00-5.70]) as well as to pPRA- (HR 3.91 [1.86-8.22]). In multivariate analysis, DSA remained of negative influence on death-censored graft survival. Flowcytometric crossmatch, MFI value, HLA class and origin of DSA were not of significant impact.ConclusionIn our cohort of (highly-) immunized recipients, pretransplant DSA led to inferior death-censored graft survival. There were no “safe” DSA characteristics since only DSA per se impacted death-censored graft survival. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1093359/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.1093359 |
| URL الوصول: |
https://doaj.org/article/edf15d26e0914e6fadd9da4b408250d7 |
| رقم الانضمام: |
edsdoj.f15d26e0914e6fadd9da4b408250d7 |
| قاعدة البيانات: |
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