Academic Journal
Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice
| العنوان: | Effect of bacillus subtilis strain Z15 secondary metabolites on immune function in mice |
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| المؤلفون: | Xi-Yuan Cao, Reyihanguli Aimaier, Jun Yang, Jing Yang, Zhong-Yi Chen, Jing-Jing Zhao, Li Yin, Qi Zhang, Jia You, Hui Zhang, Hao-Ran Li, Jia-Yi Chen, Qing-Chen Mao, Li-Ping Yang, Fei Yu, He-Ping Zhao, Hui-Xin Zhao |
| المصدر: | BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Bacillus subtilis, Secondary metabolites, Animals, Transcriptome, Immune function, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract Background Previous studies have shown that secondary metabolites of Bacillus subtilis strain Z15 (BS-Z15) are effective in treating fungal infections in mice. To evaluate whether it also modulates immune function in mice to exert antifungal effects, we investigated the effect of BS-Z15 secondary metabolites on both the innate and adaptive immune functions of mice, and explored its molecular mechanism through blood transcriptome analysis. Results The study showed that BS-Z15 secondary metabolites increased the number of monocytes and platelets in the blood, improved natural killer (NK) cell activity and phagocytosis of monocytes-macrophages, increased the conversion rate of lymphocytes in the spleen, the number of T lymphocytes and the antibody production capacity of mice, and increased the levels of Interferon gamma (IFN-γ), Interleukin-6 (IL-6), Immunoglobulin G (IgG) and Immunoglobulin M (IgM) in plasma. The blood transcriptome analysis revealed 608 differentially expressed genes following treatment with BS-Z15 secondary metabolites, all of which were significantly enriched in the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms for immune-related entries and pathways such as Tumor Necrosis Factor (TNF) and Toll-like receptor (TLR) signaling pathways, and upregulated expression levels of immune-related genes such as Complement 1q B chain (C1qb), Complement 4B (C4b), Tetracyclin Resistant (TCR) and Regulatory Factor X, 5 (RFX5). Conclusions BS-Z15 secondary metabolites were shown to enhance innate and adaptive immune function in mice, laying a theoretical foundation for its development and application in the field of immunity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| Relation: | https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-023-09313-5 |
| URL الوصول: | https://doaj.org/article/cf1591b274874834a565f8f7c4988edf |
| رقم الانضمام: | edsdoj.f1591b274874834a565f8f7c4988edf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/s12864-023-09313-5 |