التفاصيل البيبلوغرافية
| العنوان: |
Investigation on the Toxicity of Nanoparticle Mixture in Rainbow Trout Juveniles |
| المؤلفون: |
Joelle Auclair, Patrice Turcotte, Christian Gagnon, Caroline Peyrot, Kevin James Wilkinson, François Gagné |
| المصدر: |
Nanomaterials, Vol 13, Iss 2, p 311 (2023) |
| بيانات النشر: |
MDPI AG, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Chemistry |
| مصطلحات موضوعية: |
nanoparticle, mixture, oxidative stress, protein damage, genotoxicity, acetylcholinesterase, Chemistry, QD1-999 |
| الوصف: |
The environmental impacts of nanoparticle mixtures in the aquatic environment is not well understood. The purpose of this study examined the sub-lethal toxicity of low concentrations (ug/L range) of selected nanoparticles alone and in mixtures in juvenile trout. Fish were exposed to to individual and two environmentally relevant mixtures of silver (nAg), copper oxide (nCuO) and cerium oxide (nCeO) nanoparticles for 96 h at 15 °C. After the exposure period, fish were depurated overnight and tissue levels in Ag, Ce, Cu and Zn were determined along with a suite of effects biomarkers such as oxidative stress/inflammation, denatured protein tagging (ubiquitin), DNA strand breaks (genotoxicity) and acetylcholinesterase (AChE) activity. The data showed that these nanoparticles behaved as suspended matter but were nevertheless bioavailable for fish with bioconcentration factors of 6, 8 and 2 for nAg, nCeO and nCuO respectively. Only nCuO alone increased malonaldehyde (lipid peroxidation) contents but all nanoparticles increased DNA damage, protein-ubiquitin labeling, and decreased AChE activity. Globally, the toxicity of nCeO and nCuO was generally stronger than nAg, and antagonist effects were found in the mixtures. The interactions involved in these antagonisms are not well understood but do not involve the liberation of free ions and labile zinc in tissues. In conclusion, the bioavailability and toxicity of these nanoparticles are influenced by mixtures of nanoparticles, which is likely to occur in contaminated environments. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2079-4991 |
| Relation: |
https://www.mdpi.com/2079-4991/13/2/311; https://doaj.org/toc/2079-4991 |
| DOI: |
10.3390/nano13020311 |
| URL الوصول: |
https://doaj.org/article/aaf107d82fc94455bb0c4d11ec5f9aa9 |
| رقم الانضمام: |
edsdoj.f107d82fc94455bb0c4d11ec5f9aa9 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder