Academic Journal
Advancements in Dravet Syndrome Therapeutics: A Comprehensive Look at Present and Future Treatment Horizons: A Focused Review
| العنوان: | Advancements in Dravet Syndrome Therapeutics: A Comprehensive Look at Present and Future Treatment Horizons: A Focused Review |
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| المؤلفون: | Aakash Mahesan, Gautam Kamila, Sheffali Gulati |
| المصدر: | Annals of Indian Academy of Neurology, Vol 27, Iss 4, Pp 352-357 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | dravet syndrome, future therapeutics, scn1a, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Dravet syndrome (DS) is a developmental epileptic encephalopathy, characterized by fever-triggered focal or hemiclonic seizures at onset with various associated comorbidities like intellectual disability, gait abnormalities, and behavioral issues. It typically advances to drug-refractory epilepsy with multiple seizure semiology. In this review, we give a focused narrative on the treatment aspects of DS. We searched the PubMed database for articles on DS. More than 500 articles were reviewed, of which 55 relevant articles are included in this review. ClinicalTrials.gov database was also accessed for data on ongoing trials. Majority are caused by mutations in the SCN1A gene. Valproate and clobazam are the most commonly used traditional antiseizure medications. Stiripentol, fenfluramine, and cannabidiol are recently approved drugs with promising results. Ketogenic diet and vagus nerve stimulation are commonly tried nonpharmacologic modalities that have shown significant responses. Antisense oligonucleotides and viral vector-mediated gene transfer therapies are on the horizon. This review outlines the current existing treatment rationale, evidence for newly approved drugs, and the future scope of gene therapy in DS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-2327 1998-3549 |
| Relation: | https://journals.lww.com/10.4103/aian.aian_49_24; https://doaj.org/toc/0972-2327; https://doaj.org/toc/1998-3549 |
| DOI: | 10.4103/aian.aian_49_24 |
| URL الوصول: | https://doaj.org/article/df08e76c5fc348efbd377d1d782bce5d |
| رقم الانضمام: | edsdoj.f08e76c5fc348efbd377d1d782bce5d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09722327 19983549 |
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| DOI: | 10.4103/aian.aian_49_24 |