Academic Journal
Observational Cohort Study of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
| العنوان: | Observational Cohort Study of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS) |
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| المؤلفون: | Michaela Routhu, Vaclav Safka, Sunil Kumar Routhu, Tomas Fejfar, Vaclav Jirkovsky, Antonin Krajina, Eva Cermakova, Petr Hulek, Ladislav Hosak |
| المصدر: | Annals of Hepatology, Vol 16, Iss 1, Pp 140-148 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Specialties of internal medicine |
| مصطلحات موضوعية: | Creatinine, Diabetes mellitus, Ascites, Portal vein pressure, Age, Specialties of internal medicine, RC581-951 |
| الوصف: | Introduction and aim: Hepatic encephalopathy (HE) is a common complication of transjugular intrahepatic portosystemic shunting (TIPS). It is associated with a reduced quality of life and poor prognosis. The aim of this study was to compare two groups of patients who did and did not develop overt HE after TIPS. We looked for differences between these groups before TIPS. Material and Methods: A study of 895 patients was conducted based on a retrospective analysis of clinical data. Data was analyzed using Fisher's exact test, χ2, Mann Whitney test, unpaired t-test and logistic regression. After the initial analyses, we have looked at a regression models for the factors associated with development of HE after TIPS. Results: 257 (37.9%) patients developed HE after TIPS. Patients’ age, pre-TIPS portal venous pressure, serum creatinine, aspartate transaminase, albumin, presence of diabetes mellitus and etiology of portal hypertension were statistically significantly associated with the occurrence of HE after TIPS (p < 0.01). However, only the age, pre-TIPS portal venous pressure, serum creatinine, presence of diabetes mellitus and etiology of portal hypertension contributed to the regression model. Patients age, serum creatinine, presence of diabetes mellitus and portal vein pressure formed the model describing development of HE after TIPS for a subgroup of patients with refractory ascites. Conclusion: We have identified, using a substantial sample, several factors associated with the development of HE after TIPS. This could be helpful in further research. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1665-2681 16652681 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1665268119303710; https://doaj.org/toc/1665-2681 |
| DOI: | 10.5604/16652681.1226932 |
| URL الوصول: | https://doaj.org/article/f08cdace6e514b5b9605891d9e6134c5 |
| رقم الانضمام: | edsdoj.f08cdace6e514b5b9605891d9e6134c5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16652681 |
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| DOI: | 10.5604/16652681.1226932 |