Academic Journal
Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
| العنوان: | Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction |
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| المؤلفون: | Zülküf Karahan, Murat Uğurlu, Berzal Uçaman, Ali Veysel Uluğ, İlyas Kaya, Kemal Çevik, Önder Öztürk, Hikmet Iyem |
| المصدر: | Cardiology Research and Practice, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2090-8016 2090-0597 |
| Relation: | https://doaj.org/toc/2090-8016; https://doaj.org/toc/2090-0597 |
| DOI: | 10.1155/2015/363458 |
| URL الوصول: | https://doaj.org/article/f015df86a1ce4c73815df6c52bed2d0d |
| رقم الانضمام: | edsdoj.f015df86a1ce4c73815df6c52bed2d0d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20908016 20900597 |
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| DOI: | 10.1155/2015/363458 |