Academic Journal
Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery
| العنوان: | Hybrid membrane-coated nanosuspensions for multi-modal anti-glioma therapy via drug and antigen delivery |
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| المؤلفون: | Wenyan Hao, Yuexin Cui, Yueyue Fan, Mengyu Chen, Guobao Yang, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Yang Yang, Chunsheng Gao |
| المصدر: | Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-24 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biotechnology LCC:Medical technology |
| مصطلحات موضوعية: | Glioma, Blood–brain barrier, Biomimetic nanosuspensions, Chemotherapy, Immunotherapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| الوصف: | Abstract Background Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these strategies are seldom used in the clinic. The challenges facing the treatment of glioma not only involve the development of chemotherapeutic drugs and immunotherapeutic agents, but also the lack of a powerful platform that could deliver these two moieties to the targeted sites. Herein, we developed chemoimmunotherapy delivery vehicles based on C6 cell membranes and DC membranes to create hybrid membrane-coated DTX nanosuspensions (DNS-[C6&DC]m). Results Results demonstrated successful hybrid membrane fusion and nanosuspension functionalization, and DNS-[C6&DC]m could be used for different modes of anti-glioma therapy. For drug delivery, membrane coating could be applied to target the source cancer cells via a homotypic-targeting mechanism of the C6 cell membrane. For cancer immunotherapy, biomimetic nanosuspension enabled an immune response based on the professional antigen-presenting characteristic of the dendritic cell membrane (DCm), which carry the full array of cancer cell membrane antigens and facilitate the uptake of membrane-bound tumor antigens for efficient presentation and downstream immune n. Conclusion DNS-[C6&DC]m is a multifunctional biomimetic nano-drug delivery system with the potential to treat gliomas through tumor-targeted drug delivery combined with immunotherapy, thereby presenting a promising approach that may be utilized for multiple modes of cancer therapy. Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-021-01110-0 |
| URL الوصول: | https://doaj.org/article/bfaa27664be04457b661bbf87d68f7f0 |
| رقم الانضمام: | edsdoj.bfaa27664be04457b661bbf87d68f7f0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14773155 |
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| DOI: | 10.1186/s12951-021-01110-0 |