Academic Journal
The crucial roles and research advances of cGAS‑STING pathway in liver diseases
| العنوان: | The crucial roles and research advances of cGAS‑STING pathway in liver diseases |
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| المؤلفون: | Xiaoqian Zhang, Bin He, Juan Lu, Qiongling Bao, Jie Wang, Yida Yang |
| المصدر: | Annals of Medicine, Vol 56, Iss 1 (2024) |
| بيانات النشر: | Taylor & Francis Group, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | cGAS-STING, liver inflammation, innate immunity, mechanism, inhibitors, Medicine |
| الوصف: | Inflammation responses have identified as a key mediator of in various liver diseases with high morbidity and mortality. cGAS-STING signalling is essential in innate immunity since it triggers release of type I interferons and various of proinflammatory cytokines. The potential connection between cGAS-STING pathway and liver inflammatory diseases has recently been reported widely. In our review, the impact of cGAS-STING on liver inflammation and regulatory mechanism are summarized. Furthermore, many inhibitors of cGAS-STING signalling as promising agents to cure liver inflammation are also explored in detail. A comprehensive knowledge of molecular mechanisms of cGAS-STING signalling in liver inflammation is vital for exploring novel treatments and providing recommendations and perspectives for future utilization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 07853890 1365-2060 0785-3890 |
| Relation: | https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060 |
| DOI: | 10.1080/07853890.2024.2394588 |
| URL الوصول: | https://doaj.org/article/bf70e10d841944eaa79a63dc720bb578 |
| رقم الانضمام: | edsdoj.bf70e10d841944eaa79a63dc720bb578 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 07853890 13652060 |
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| DOI: | 10.1080/07853890.2024.2394588 |