التفاصيل البيبلوغرافية
العنوان: |
Mortality and health-related quality of life in older adults with long-term use of opioids, z-hypnotics or benzodiazepines: a prospective observational study at 5 years follow-up |
المؤلفون: |
Christofer Lundqvist, Socheat Cheng, Ramune Grambaite, Jūratė Šaltytė Benth, Maria Torheim Bjelkarøy, Tone Breines Simonsen, Tahreem Ghazal Siddiqui, |
المصدر: |
BMJ Open, Vol 14, Iss 2 (2024) |
بيانات النشر: |
BMJ Publishing Group, 2024. |
سنة النشر: |
2024 |
المجموعة: |
LCC:Medicine |
مصطلحات موضوعية: |
Medicine |
الوصف: |
Objectives Disease and medication use in older age is a consequence of age-related declining health. Multimorbidity followed by polypharmacy is common. Central nervous system depressing (CNSD) drugs such as opioids, benzodiazepines and z-hypnotics are not recommended for long-term use in older adults but are in use by many. We aimed to assess mortality and change in health-related quality of life (HRQoL) in older adults with long-term use of CNSDs.Method A prospective observational study was conducted at Akershus University Hospital, Norway, 2017–2019, with follow-up in 2021–2022, including 246 participants aged 65–90. At 5-year follow-up, 78 (32%) participants had passed away. Mortality data were collected from patient electronic health records. Of the surviving 168 (68%), we collected further follow-up data from 38 (16%) participants. Follow-up included demographic and clinical data. The EuroQuol Group EQ-5D-5L questionnaire was used to measure HRQoL. Analysis include Cox regression model for survival data and linear mixed model for change in HRQoL over time.Results At follow-up, 78 (31.7%) were deceased. Mean survival time was 3.3 years. Total time for survival data was 4.7 years. Mortality was higher among participants with long-term use of CNSD (HR 1.9 95% CI (1.2 to 3.2), p=0.01). The multivariable analysis found being older (HR 1.1 95% CI (1.0 to 1.1), p=0.020) and male sex (HR 2.1 95% CI (1.2 to 3.5), p=0.008) to be associated with increased risk of mortality. According to the linear mixed model (n=38), there was no significant difference between surviving users and non-users in change in HRQoL EQ-5D-5L index from baseline to follow-up.Conclusion Mortality was higher for long-term users of CNSDs at 5-year follow-up. Being older and male sex were associated with mortality. Among survivors, there was no significant difference between the groups in change of HRQoL over time.Trial registration number NCT03162081; 22 May 2017. |
نوع الوثيقة: |
article |
وصف الملف: |
electronic resource |
اللغة: |
English |
تدمد: |
2044-6055 |
Relation: |
https://bmjopen.bmj.com/content/14/2/e079347.full; https://doaj.org/toc/2044-6055 |
DOI: |
10.1136/bmjopen-2023-079347 |
URL الوصول: |
https://doaj.org/article/bf26037fac534adc977e4593661dadbd |
رقم الانضمام: |
edsdoj.bf26037fac534adc977e4593661dadbd |
قاعدة البيانات: |
Directory of Open Access Journals |